Fig. 4. Hydrogel particle size and gelation mechanism.

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Fig. 4. Hydrogel particle size and gelation mechanism. Hydrogel particle size and gelation mechanism. (A) N95BA5 particle size as assessed using dynamic light scattering in solution below LCST (2°C), showing a 96% scattering intensity for small-radius particles. (B) Particle size in the phase transition region (12°C). A split was observed between particles with hydrodynamic radius of 4.5 and 236.2 nm. (C) Particle size toward the end of the phase transition region (18°C). Ninety-eight percent of scattering intensity was due to large-radius N95BA5 aggregates. (D to F) Hydrodynamic radius size of particles traced through the hydrogel transition to show higher aggregate populations at higher temperatures (n = 3 per temperature). (G) Gross images of molded hydrogel samples held at the expected eye temperature (32°C) for up to 30 days, showing slight volume decrease and good shape persistence and stability. Niki Bayat et al., Sci Transl Med 2017;9:eaan3879 Published by AAAS