Mean ADHD-RS-IV Scores at End Point

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Mean ADHD-RS-IV Scores at End Point 30 25 20 Mean ADHD-RS-IV Total Score 15 10 5 Baseline 1 4 6 12 18 24 End point Months Placebo Part A active treatment four-week double-blind study Part B active treatment six-month open-label study Adapted from Cutler A. APA 2007, Abstract NR654.

Patient improvement (%) Improvements in CGI-I Scores 90 80 70 60 50 Patient improvement (%) 40 30 20 10 * Month 1 4 6 12 18 24 End point Double-blind phase Open-label extension Placebo part A Active treatment part A Active treatment part B *No participants received placebo, hence value at 24 months is 0. Adapted from Weisler R. APA 2007, Abstract NR650.

Mean Changes in Pulse and Heart Rate 6 Mean pulse rate 5 Mean heart rate 4 3 2 Active treatment Part B Pulse and heart rate (bpm) 1 Placebo Part A Active treatment Part A -1 -2 -3 -4 Double-blind Open-label All patients Adapted from Weisler R. APA 2007, Abstract NR652.