Change of right heart size and function by long-term therapy with riociguat in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension  Alberto M. Marra, Benjamin Egenlauf, Nicola Ehlken, Christine Fischer, Christina Eichstaedt, Christian Nagel, Eduardo Bossone, Antonio Cittadini, Michael Halank, Henning Gall, Karen M. Olsson, Tobias J. Lange, Ekkehard Grünig  International Journal of Cardiology  Volume 195, Pages 19-26 (September 2015) DOI: 10.1016/j.ijcard.2015.05.105 Copyright © 2015 Terms and Conditions

Fig. 1 Flow-chart of study population. Number of patients included in the analysis, exclusions and loss to follow-up are given for each time point. International Journal of Cardiology 2015 195, 19-26DOI: (10.1016/j.ijcard.2015.05.105) Copyright © 2015 Terms and Conditions

Fig. 2 Individual RA area at baseline and after 1year. RA areas for each patient are given for baseline and 12months, circles for females and triangles for males. The corresponding cut-off values with 15cm2 for females (dashed) and 16cm2 for males (straight) are given as horizontal and vertical lines. The diagonal represents no change between time points. International Journal of Cardiology 2015 195, 19-26DOI: (10.1016/j.ijcard.2015.05.105) Copyright © 2015 Terms and Conditions

Fig. 3 Mean RV area during the course of the study. For each time point mean RV area±standard error of the mean is given. p-Values are given compared to baseline for all analyses. The complete case analysis is given as straight line, the last observation carried forward as dashed line and baseline observation carried forward as dotted line. Mean RV area significantly decreased at all time-points compared to baseline. Results of the two imputation methods showed the same significances with smaller effect sizes. International Journal of Cardiology 2015 195, 19-26DOI: (10.1016/j.ijcard.2015.05.105) Copyright © 2015 Terms and Conditions

Fig. 4 Mean RA area during the course of the study. For each time point mean RV area±standard error of the mean is given. p-Values are given compared to baseline for all analyses. The complete case analysis is given as straight line, the last observation carried forward as dashed line and baseline observation carried forward as dotted line. Mean RA area significantly decreased after 12months compared to baseline. Results of the two imputation methods showed the same significances with smaller effect sizes. International Journal of Cardiology 2015 195, 19-26DOI: (10.1016/j.ijcard.2015.05.105) Copyright © 2015 Terms and Conditions

Fig. 5 Mean TAPSE during the course of the study. For each time point mean RV area±standard error of the mean is given. p-Values are given compared to baseline for all analyses. The complete case analysis is given as straight line, the last observation carried forward as dashed line and baseline observation carried forward as dotted line. Mean TAPSE significantly decreased after 6 and 12months compared to baseline. International Journal of Cardiology 2015 195, 19-26DOI: (10.1016/j.ijcard.2015.05.105) Copyright © 2015 Terms and Conditions