Once-Daily Gastroretentive Gabapentin for Postherpetic Neuralgia: Integrated Efficacy, Time to Onset of Pain Relief and Safety Analyses of Data From Two.

Slides:

Advertisements

Similar presentations

Treatment of postherpetic neuralgia: a review of therapeutic options Charles E. Argoff, MD, Nathaniel Katz, MD, Miroslav Backonja, MD Journal of Pain and.

Advertisements

Spinal Cord and Peripheral Nerve Stimulation Techniques for Neuropathic Pain Oscar A. de Leon-Casasola, MD Journal of Pain and Symptom Management Volume.

Comparison of the Constipation Assessment Scale and Plain Abdominal Radiography in the Assessment of Constipation in Advanced Cancer Patients Kittiphon.

Management of Phantom Pain with a Textile, Electromagnetically-Acting Stump Liner: A Randomized, Double-Blind, Crossover Study Uwe Kern, MD, Bernd Altkemper,

Oropharyngeal Mucositis Pain Treatment with Transdermal Buprenorphine in Patients After Allogeneic Stem Cell Transplantation Samuel Vokurka, MD, PhD

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of Shuangbai San for Treating Primary Liver Cancer Patients With Cancer Pain Xiaowei.

One-Year rTMS Treatment for Refractory Trigeminal Neuralgia

Chronic Pain Management in Older Adults: Special Considerations

Managing Metastatic Bone Pain: The Role of Bisphosphonates

Treating acute rhinosinusitis: Comparing efficacy and safety of mometasone furoate nasal spray, amoxicillin, and placebo Eli O. Meltzer, MD, Claus Bachert,

Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study of the Efficacy, Safety, and Tolerability of THC:CBD Extract and THC Extract.

Clinical Trial Results with OROS® Hydromorphone

Managing Metastatic Bone Pain: The Role of Bisphosphonates

Wen Jing Chung, MD, MS, Gregory H. Pharo, DO

Olanzapine for the Prevention of Chemotherapy-Induced Nausea and Vomiting in Patients Receiving Highly or Moderately Emetogenic Chemotherapy: A Randomized,

A Randomized, Double-Blind, Placebo-Controlled Study of Intrathecal Ziconotide in Adults with Severe Chronic Pain Richard L. Rauck, MD, Mark S. Wallace,

An Effective Treatment of Severe Complex Regional Pain Syndrome Type 1 in a Child Using High Doses of Intrathecal Ziconotide Michael Stanton-Hicks, MD,

Chronic Pain Management in Older Adults: Special Considerations

Edmonton, Canada: A Regional Model of Palliative Care Development

Reliability, Validity, and Responsiveness of the Daily Sleep Interference Scale Among Diabetic Peripheral Neuropathy and Postherpetic Neuralgia Patients

Hospice and Palliative Care Development in Africa: A Multi-Method Review of Services and Experiences David Clark, PhD, Michael Wright, PhD, Jennifer.

A Double-Blind, Placebo-Controlled, Crossover Pilot Trial With Extension Using an Oral Mucosal Cannabinoid Extract for Treatment of Chemotherapy-Induced.

David M. Simpson, MD, Lydia Estanislao, MD, Stephen J

Efficacy and Safety of the Seven-Day Buprenorphine Transdermal System in Opioid- Naïve Patients with Moderate to Severe Chronic Low Back Pain: An Enriched,

What Palliative Care-Related Problems Do Patients Experience at HIV Diagnosis? A Systematic Review of the Evidence Victoria M. Simms, MSc, Irene J. Higginson,

Use of the Cumulative Proportion of Responders Analysis Graph to Present Pain Data Over a Range of Cut-Off Points: Making Clinical Trial Data More Understandable

What Influences Patients’ Decisions on Artificial Hydration at the End of Life? A Q- Methodology Study Catherine Malia, MSc, Michael I. Bennett, MB, ChB,

Oropharyngeal Mucositis Pain Treatment with Transdermal Buprenorphine in Patients After Allogeneic Stem Cell Transplantation Samuel Vokurka, MD, PhD

Eduardo Bruera, MD, Raul Sala, MD, Odette Spruyt, MD, J

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of Shuangbai San for Treating Primary Liver Cancer Patients With Cancer Pain Xiaowei.

Double-Blind, Placebo-Controlled Trial of Lamotrigine in Combination with Other Medications for Neuropathic Pain Marianne Silver, MS, David Blum, MD,

Long-Term Safety of NGX-4010, a High-Concentration Capsaicin Patch, in Patients with Peripheral Neuropathic Pain David M. Simpson, MD, Suzanne Gazda,

A randomized, double-blind, crossover study of the use of transcutaneous spinal electroanalgesia in patients with pain from chronic critical limb ischemia

Tetrodotoxin for Moderate to Severe Cancer Pain: A Randomized, Double Blind, Parallel Design Multicenter Study Neil A. Hagen, MD, FRCPC, Patrick du Souich,

What Can We Learn About the Spiritual Needs of Palliative Care Patients From the Research Literature? Mark Cobb, MA, Christopher Dowrick, MD, FRCGP,

One-Year rTMS Treatment for Refractory Trigeminal Neuralgia

Regulating Palliative Care: The Case of Hospice

David Clark, PhD, Michael Wright, PhD

Apremilast, an oral phosphodiesterase 4 inhibitor, in patients with difficult-to-treat nail and scalp psoriasis: Results of 2 phase III randomized, controlled.

Redefining Appropriate Treatment Expectations

Treatment of Cancer Pain with Noninvasive Brain Stimulation

Integrating Palliative Care into National Policies

Jodi L. Hannan, MD, Steven M. Radwany, MD, Terry Albanese, PhD

Amitriptyline in the Treatment of Chemotherapy-Induced Neuropathic Symptoms Anna-Liisa Kautio, MD, Maija Haanpää, MD, PhD, Tiina Saarto, MD, PhD, Eija.

Barrie R. Cassileth, PhD, Andrew J. Vickers, PhD

Robert L. Jayes, MD, Robert M. Arnold, MD, Erik K. Fromme, MD

Susan C. Miller, PhD, Dan K. Kiely, MPH, MA, Joan M

Effects of Methylphenidate on Fatigue and Depression: A Randomized, Double-Blind, Placebo-Controlled Trial Christopher W. Kerr, MD, PhD, Julie Drake,

U.S. Hospice Benefits Journal of Pain and Symptom Management

Randomized, Double-Blind, Placebo-Controlled Trial of Oral Docusate in the Management of Constipation in Hospice Patients Yoko Tarumi, MD, Mitchell P.

Development and Reliability Testing of the Victoria Bowel Performance Scale (BPS) G. Michael Downing, MD, Craig Kuziemsky, PhD, Mary Lesperance, PhD,

Association Between Symptom Distress and Survival in Outpatients Seen in a Palliative Care Cancer Center J. Lynn Palmer, PhD, Michael J. Fisch, MD, MPH

A New Approach to Eliciting Patients' Preferences for Palliative Day Care: The Choice Experiment Method Hannah-Rose Douglas, PhD, Charles E. Normand,

Comparative Efficacy of Oral Extended-Release Hydromorphone and Immediate- Release Hydromorphone in Patients with Persistent Moderate to Severe Pain: Two.

Gabapentin and an Opioid Combination Versus Opioid Alone for the Management of Neuropathic Cancer Pain: A Randomized Open Trial Kader Keskinbora, MD,

Treating acute rhinosinusitis: Comparing efficacy and safety of mometasone furoate nasal spray, amoxicillin, and placebo Eli O. Meltzer, MD, Claus Bachert,

Clinical and Economic Impact of Palliative Care Consultation

Efficacy and Safety of Transdermal Buprenorphine: A Randomized, Placebo-Controlled Trial in 289 Patients with Severe Cancer Pain Philippe Poulain, MD,

Efficacy of Darbepoetin Alfa in Alleviating Fatigue and the Effect of Fatigue on Quality of Life in Anemic Patients with Lymphoproliferative Malignancies

Subcutaneous Methylnaltrexone for the Treatment of Opioid-Induced Constipation in Patients with Advanced Illness: A Double-Blind, Randomized, Parallel.

Nathaniel P Katz, MD Journal of Pain and Symptom Management

Management of Phantom Pain with a Textile, Electromagnetically-Acting Stump Liner: A Randomized, Double-Blind, Crossover Study Uwe Kern, MD, Bernd Altkemper,

Botucatu, Brazil: A Regional Community Palliative Care Model

Amy P. Abernethy, MD Journal of Pain and Symptom Management

Scrambler Therapy May Relieve Chronic Neuropathic Pain More Effectively Than Guideline-Based Drug Management: Results of a Pilot, Randomized, Controlled.

Helping Patients with Advanced Cancer Live with Concerns About Eating: A Challenge for Palliative Care Professionals Jane Hopkinson, PhD, RGN, Jessica.

Apremilast, an oral phosphodiesterase-4 inhibitor, in the treatment of palmoplantar psoriasis: Results of a pooled analysis from phase II PSOR-005 and.

Associations Between Physical Activity and Quality of Life in Cancer Patients Receiving Palliative Care: A Pilot Survey Sonya S. Lowe, MD, MSc, Sharon.

Randomized Double-Blind Trial of Sublingual Atropine vs

Efficacy and Safety of the Seven-Day Buprenorphine Transdermal System in Opioid- Naïve Patients with Moderate to Severe Chronic Low Back Pain: An Enriched,

Presentation transcript:

Once-Daily Gastroretentive Gabapentin for Postherpetic Neuralgia: Integrated Efficacy, Time to Onset of Pain Relief and Safety Analyses of Data From Two Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Studies Richard L. Rauck, MD, Gordon A. Irving, MD, Mark S. Wallace, MD, Geertrui F. Vanhove, MD, PhD, Michael Sweeney, MD Journal of Pain and Symptom Management Volume 46, Issue 2, Pages 219-228 (August 2013) DOI: 10.1016/j.jpainsymman.2012.07.011 Copyright © 2013 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 1 a) Patients randomized and b) patients treated. ∗n=1 did not receive study drug; qd = once daily; bid = twice daily (600 mg AM, 1200 mg PM); ITT=intent-to-treat; G-GR=gastroretentive gabapentin. Journal of Pain and Symptom Management 2013 46, 219-228DOI: (10.1016/j.jpainsymman.2012.07.011) Copyright © 2013 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 2 Absolute and percent change in ADP score from baseline to Week 10. ADP=average daily pain; G-GR=gastroretentive gabapentin. Journal of Pain and Symptom Management 2013 46, 219-228DOI: (10.1016/j.jpainsymman.2012.07.011) Copyright © 2013 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 3 Mean percent change in ADP score by day. G-GR showed greater improvement in mean pain scores than placebo (P<0.05) for all days except Days 1 and 65. Values shown are LS mean (SEM), estimated from the analysis of covariance model that includes treatment and center factors and baseline as a covariate. LS=least square; ADP=average daily pain; G-GR=gastroretentive gabapentin. Journal of Pain and Symptom Management 2013 46, 219-228DOI: (10.1016/j.jpainsymman.2012.07.011) Copyright © 2013 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 4 Time to onset of pain relief. G-GR=gastroretentive gabapentin. Journal of Pain and Symptom Management 2013 46, 219-228DOI: (10.1016/j.jpainsymman.2012.07.011) Copyright © 2013 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 5 Percentage of patients responding with ≥30% and ≥50% reduction in last observation carried forward ADP score from baseline. The P-value is based on the z-test for the difference in proportions between two groups. ADP=average daily pain; G-GR=gastroretentive gabapentin. Journal of Pain and Symptom Management 2013 46, 219-228DOI: (10.1016/j.jpainsymman.2012.07.011) Copyright © 2013 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 6 PGIC and CGIC. Percent of patients in “very much improved” and “much improved” categories are combined. The P-value is from Fisher's exact test. PGIC=Patient Global Impression of Change; CGIC=Clinical Global Impressions of Change; G-GR=gastroretentive gabapentin. Journal of Pain and Symptom Management 2013 46, 219-228DOI: (10.1016/j.jpainsymman.2012.07.011) Copyright © 2013 U.S. Cancer Pain Relief Committee Terms and Conditions