Neurobiology: The acid test for resting potassium channels

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Neurobiology: The acid test for resting potassium channels David A. Brown Current Biology Volume 10, Issue 12, Pages R456-R459 (June 2000) DOI: 10.1016/S0960-9822(00)00532-7

Figure 1 Topology of the pore-forming subunits of the major families of K+ channels. Transmembrane domains are shaded yellow and the pore loops are shaded red. (a) The one pore, six transmembrane domain family includes the Shaker/Shal/Shab/Shaw (Kv1–4), KCNQ, Eag, Erg, Elk and Slo subfamilies of voltage gated channels. The voltage-sensing S4 transmembrane domain is shaded green. (b) The one pore, two transmembrane domain includes the inward rectifier (Kir) channels. (c,d) The two groups of twin-pore channels; note that these do not have a ‘voltage sensor’. TASK belongs to the two-pore, four transmembrane domain group (d). Current Biology 2000 10, R456-R459DOI: (10.1016/S0960-9822(00)00532-7)