CARD15/NOD2 Mutational Analysis and Genotype-Phenotype Correlation in 612 Patients with Inflammatory Bowel Disease  Suzanne Lesage, Habib Zouali, Jean-Pierre Cézard, Jean-Frédéric Colombel, Jacques Belaiche, Sven Almer, Curt Tysk, Colm O'Morain, Miquel Gassull, Vibeke Binder, Yigael Finkel, Robert Modigliani, Corinne Gower-Rousseau, Jeanne Macry, Françoise Merlin, Mathias Chamaillard, Anne-Sophie Jannot, Gilles Thomas, Jean-Pierre Hugot  The American Journal of Human Genetics  Volume 70, Issue 4, Pages 845-857 (April 2002) DOI: 10.1086/339432 Copyright © 2002 The American Society of Human Genetics Terms and Conditions

Figure 1 Distribution of the nine most frequent variants and the group of rare sequence variants observed in CARD15 gene in CD, UC, and control populations. Allele frequencies of these variants in CD and UC populations were compared with those in the control group, and the level of significance (P value) is denoted here by asterisks: *, P<.05; **, P<.005; ***, P<.0005. The American Journal of Human Genetics 2002 70, 845-857DOI: (10.1086/339432) Copyright © 2002 The American Society of Human Genetics Terms and Conditions

Figure 2 Distribution of the DCMs along the CARD15/NOD2 protein and number of mutated chromosomes observed among the patients with CD. The asterisk (*) denotes that the P268S mutation was not considered, because of its tight linkage disequilibrium with other variants (see text). The American Journal of Human Genetics 2002 70, 845-857DOI: (10.1086/339432) Copyright © 2002 The American Society of Human Genetics Terms and Conditions