CALming Down T Cell Acute Leukemia

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CALming Down T Cell Acute Leukemia Emilio Hirsch, Roberto Chiarle  Cancer Cell  Volume 21, Issue 4, Pages 449-450 (April 2012) DOI: 10.1016/j.ccr.2012.03.025 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 Role of PI3Kδ and PI3Kγ Isoforms in the Development of Normal Thymocytes and T-ALL (Top) Signal transduction events leading to differentiation of T cells from the double negative (DN) to the double positive (DP) stage. (Bottom) Loss of PTEN leads to unrestrained p110γ and δ activity and T-ALL. The use of the drug CAL-130 inhibits these two p110 PI3K isoforms, thus blocking T-ALL. Cancer Cell 2012 21, 449-450DOI: (10.1016/j.ccr.2012.03.025) Copyright © 2012 Elsevier Inc. Terms and Conditions

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