Permeability of the rat small intestinal epithelium along the villus-crypt axis: Effects of glucose transport Britt–Marie Fihn, Anders Sjöqvist, Mats.

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Presentation transcript:

Permeability of the rat small intestinal epithelium along the villus-crypt axis: Effects of glucose transport Britt–Marie Fihn, Anders Sjöqvist, Mats Jodal Gastroenterology Volume 119, Issue 4, Pages 1029-1036 (October 2000) DOI: 10.1053/gast.2000.18148 Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 1 Clearance of mannitol, Cr-EDTA, and inulin from luminal perfusates containing either 30 mmol/L mannitol or glucose (perfusion rate, 0.5 mL/min) and of mannitol and Cr-EDTA (perfusion rate, 0.2 mL/min). The mannitol values (perfusion rate, 0.5 mL/min) are the compiled data from the 51Cr-EDTA/14C-mannitol and 14C-mannitol/3H-inulin series. Bars denote ±SE. Significances between values and number of observations (n) are shown in Table 1. Gastroenterology 2000 119, 1029-1036DOI: (10.1053/gast.2000.18148) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 2 Clearance of mannitol, Cr-EDTA, and inulin from luminal perfusates containing either 30 mmol/L mannitol or glucose during nicotinic receptor blockade by hexamethonium (10 μg/kg intravenously) administered every 45 minutes. The mannitol values are the compiled data from the 51Cr-EDTA/14C-mannitol and 14C-mannitol/3H-inulin series. Bars denote ±SE. Significances between values and number of observations (n) are shown in Table 2. Gastroenterology 2000 119, 1029-1036DOI: (10.1053/gast.2000.18148) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 3 Relationship between net fluid transport and clearance of the different permeability probes in all series in this study. The exact values and SE values are shown in Tables 1 and 2. The linear regression equation for clearance of Cr-EDTA is y = 0.09x + 1.04, for mannitol with KM solution y = 0.33x + 4.01, and with KG solution y = 1.15x + 15.03. Gastroenterology 2000 119, 1029-1036DOI: (10.1053/gast.2000.18148) Copyright © 2000 American Gastroenterological Association Terms and Conditions