Candida albicans Adds More Weight to Iron Regulation

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Presentation transcript:

Candida albicans Adds More Weight to Iron Regulation Jill R. Blankenship, Aaron P. Mitchell Cell Host & Microbe Volume 10, Issue 2, Pages 93-94 (August 2011) DOI: 10.1016/j.chom.2011.08.001 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 Model for Niche-Dependent Functions of C. albicans Iron Regulators During growth in the bloodstream (top), transcription factors Sef1 and Hap43 are expressed and functional. Sef1 promotes expression of iron uptake genes and several virulence genes. Hap43 represses iron utilization genes and SFU1. During growth in the GI tract (bottom), transcription factor Sfu1 represses iron uptake genes and SEF1, thus indirectly repressing HAP43 as well. This state causes elevated expression of iron utilization genes. Cell Host & Microbe 2011 10, 93-94DOI: (10.1016/j.chom.2011.08.001) Copyright © 2011 Elsevier Inc. Terms and Conditions