Narcotic analgesic Drugs

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Presentation transcript:

Narcotic analgesic Drugs BY Dr. Mirza Shahed Baig

WHAT IS PAIN Pain is a crucial aspect of the body’s defense mechanisms Pain “is a part of a rapid warning relay instruction the motor neurons of the central nervous system to minimize detected physical harm ”

Some of the most common causes of pain include: headache postsurgical pain post-trauma pain lower back pain cancer pain arthritis pain neurogenic pain (pain caused by nerve damage) psychogenic pain (pain that isn’t caused by disease, injury, or nerve damage)

Degree of Pain

Centrally Acting Analgesics

Morphine and its derivatives

Sources of Morphines

Poppy plant

Natural Opium Alkaloids

Morphine Side effects

Morphine binding to its Receptors

MORPHINE MOA

Metabolism of Morphine

Metabolism of Morphine

Chemistry of Morphine

Chemistry of Morphine Early Changes on Morphine Nucleus (Before 1929) Modification carried out by Small, Eddy and Co-workers ( After 1929) Modification carried out by Eisleb and Shaumann (1938) Modification carried out by Grewes (After 1946)

Early Changes on Morphine Nucleus (Before 1929)

Early Changes on Morphine Nucleus (Before 1929)

Early Changes on Morphine Nucleus (Before 1929)

Modification carried out by Small, Eddy and Co-workers ( After 1929)

Modification in Aromatic Ring

Modification in Aromatic Ring

Modification in Aromatic Ring

Modification in Alicyclic Ring

Modification in Alicyclic Ring

Modification in Alicyclic Ring

Modification in Alicyclic Ring

Modification in Alicyclic Ring

Modification in Tetrahydrofuran Ring

Modification at tert. N atom.

Modification at tert. N atom.

Modification carried out by Eisleb and Shaumann (1938)

Modification carried out by Eisleb and Shaumann (1938) Meperidine Series Bemidones Series Prodines Series Fentanyl Series Methadone Series

Modification carried out by Eisleb and Shaumann (1938)

Meperidine, Bemidones, Prodines

Fentanyl Series

Methadone Series

Methadone Series

Modification carried out by Grewes (After 1946)

Morphinan Series

Benzomorphan Series

Opioid Antagonists