Volume 68, Issue 3, Pages 609-610 (March 2018) Nucleos(t)ide analogue interruption: Alternative approach to intrahepatic set point for spontaneous control of HBV replication?  Yiqi Yu, Jing Wang, Guojun Li, Chuan Shen, Shaolong Chen, Jun Huang, Xinyu Wang, Caiyan Zhao, Yuxian Huang, Bin Wang, Xuanyi Wang, Jiming Zhang, Chao Qiu, Wenhong Zhang  Journal of Hepatology  Volume 68, Issue 3, Pages 609-610 (March 2018) DOI: 10.1016/j.jhep.2017.09.026 Copyright © 2017 European Association for the Study of the Liver Terms and Conditions

Fig. 1 Levels of viral replicative forms and spontaneous control of HBV replication. (A) Levels of serum HBV-RNA, (B) intrahepatic HBV-RNA, (C) intrahepatic total HBV DNA, (D) and cccDNA under ETV treatment in comparison to those of IA and IC patients. Level of cccDNA in one ETV-treated case, one IC case and one IA case were below the lower detectable limit. ETV, HBeAg-negative patients receiving ETV treatment; IA, HBeAg-negative patients in the immune-active phase who were naive to treatment, also known as HBeAg-negative chronic hepatitis B; IC, inactive carrier, also known as HBeAg-negative HBV infection (Mann–Whitney test, *p <0.05; **p <0.01; ***p <0.001). cccDNA, covalently closed circular DNA; ETV, entecavir; HBeAg, hepatits B e-antigen; HBV, hepatitis B virus. Journal of Hepatology 2018 68, 609-610DOI: (10.1016/j.jhep.2017.09.026) Copyright © 2017 European Association for the Study of the Liver Terms and Conditions