Periodontal Pocket Depth, Hyperglycemia, and Progression of Chronic Kidney Disease: A Population-Based Longitudinal Study Jia-Feng Chang, MD, Jih-Chen.

Slides:

Advertisements

Similar presentations

Low-Dose Aspirin in Patients with Stable Cardiovascular Disease: A Meta-analysis Jeffrey S. Berger, MD, MS, David L. Brown, MD, Richard C. Becker, MD The.

Advertisements

Effects of structured care by a pharmacist-diabetes specialist team in patients with Type 2 diabetic nephropathy Wilson Y.S. Leung, BPharm, PhD, Wing-Yee.

Hypertension Awareness, Treatment, and Control in Chronic Kidney Disease Pantelis A. Sarafidis, MD, PhD, Suying Li, PhD, Shu-Cheng Chen, MS, Allan J.

The Effect of Smoking on the Risk of Sciatica: A Meta-analysis

The Diabetes Shared Care Program and Risks of Cardiovascular Events in Type 2 Diabetes Edy Kornelius, MD, Jeng-Yuan Chiou, PhD, Yi-Sun Yang, PhD, MD,

Grip Strength Predicts Cause-Specific Mortality in Middle-Aged and Elderly Persons Hideo Sasaki, MD, PhD, Fumiyoshi Kasagi, PhD, Michiko Yamada, MD, PhD,

Dipeptidyl Peptidase-4 Inhibitors, Peripheral Arterial Disease, and Lower Extremity Amputation Risk in Diabetic Patients Chun-Chin Chang, MD, Yung-Tai.

Longitudinal Patterns of Cardiorespiratory Fitness Predict the Development of Hypertension Among Men and Women Xuemei Sui, MD, MPH, PhD, Mark A. Sarzynski,

Impact of More Restrictive Blood Transfusion Strategies on Clinical Outcomes: A Meta- analysis and Systematic Review Shelley R. Salpeter, MD, Jacob S.

Aruna D. Pradhan, MD, Nader Rifai, PhD, Julie E. Buring, ScD, Paul M

Emilee R. Wilhelm-Leen, BA, Yoshio N. Hall, MD, Manjula K

Prevalence, Predictors, and Outcomes in Treatment-resistant Hypertension in Patients with Coronary Disease Sripal Bangalore, MD, MHA, Rana Fayyad, PhD,

Samy Suissa, PhD, Abbas Kezouh, PhD, Pierre Ernst, MD, MSc

Matthew I. Worthley, MBBS, PhD, FRACP, Fiona M

The Burden of Modifiable Risk Factors in Newly Defined Categories of Blood Pressure Anna Gu, MD, PhD, Yu Yue, PhD, Joohae Kim, PharmD Candidate, Edgar.

30-Day Readmissions After an Acute Kidney Injury Hospitalization

CHA2DS2-VASc Score Is Directly Associated with the Risk of Pulmonary Embolism in Patients with Atrial Fibrillation Walid Saliba, MD, MPH, Gad Rennert,

Usefulness of the Visceral Adiposity Index in Different Populations

Apolipoprotein E-containing high-density lipoprotein (HDL) modifies the impact of cholesterol-overloaded HDL on incident coronary heart disease risk:

Pyogenic Liver Abscess as the Initial Manifestation of Underlying Hepatocellular Carcinoma Yi-Tsung Lin, MD, Chia-Jen Liu, MD, Tzeng-Ji Chen, MD, Te-Li.

Prognostic Importance of Low Admission Serum Creatinine Concentration for Mortality in Hospitalized Patients Charat Thongprayoon, MD, Wisit Cheungpasitporn,

The association of chronic kidney disease and dialysis treatment with foot ulceration and major amputation Jeroen Otte, MD, MSc, Jaap J. van Netten,

Body Mass Index and Mortality in Acute Myocardial Infarction Patients

Risk of ESRD and Mortality in Kidney and Bladder Stone Formers

Blood Lead Levels and Decreased Kidney Function in a Population-Based Cohort Florencia Harari, Gerd Sallsten, Anders Christensson, Marinka Petkovic, Bo.

The Impact of Race on the Prognosis of Preclinical Diastolic Dysfunction: A Large Multiracial Urban Population Study Jian Shan, MD, Lili Zhang, MD, MSc,

Comparison of the Performance of 2 GFR Estimating Equations Using Creatinine and Cystatin C to Predict Adverse Outcomes in Elderly Individuals Insa E.

Primacy of the 3B Approach to Control Risk Factors for Cardiovascular Disease in Type 2 Diabetes Patients Linong Ji, MD, Dayi Hu, MD, Changyu Pan, MD,

Sabina Hunziker, MD, MPH, Jennifer Stevens, MD, MS, Michael D

Dipeptidyl Peptidase-4 Inhibitors, Peripheral Arterial Disease, and Lower Extremity Amputation Risk in Diabetic Patients Chun-Chin Chang, MD, Yung-Tai.

Hypertensive Disorders in Pregnancy and Subsequent Diabetes Mellitus: A Retrospective Cohort Study I-Kuan Wang, MD, I-Ju Tsai, MS, Pei-Chun Chen, PhD,

CHADS2 Score, Statin Therapy, and Risks of Atrial Fibrillation

The Reply The American Journal of Medicine

Blood Lead Levels and Decreased Kidney Function in a Population-Based Cohort Florencia Harari, Gerd Sallsten, Anders Christensson, Marinka Petkovic, Bo.

The association of chronic kidney disease and dialysis treatment with foot ulceration and major amputation Jeroen Otte, MD, MSc, Jaap J. van Netten,

Gout in African Americans

Matthew W. Parker, MD, Murray A. Mittleman, MD, DrPH, Carol A

Chronic Kidney Disease, Basal Insulin Glargine, and Health Outcomes in People with Dysglycemia: The ORIGIN Study Vasilios Papademetriou, MD, DSc, Eric.

Longitudinal Patterns of Cardiorespiratory Fitness Predict the Development of Hypertension Among Men and Women Xuemei Sui, MD, MPH, PhD, Mark A. Sarzynski,

Interaction of Physical Activity and Body Mass Index on Mortality in Coronary Heart Disease: Data from the Nord-Trøndelag Health Study Trine Moholdt,

Your Kidneys May Outlive You

The Natural Course of Microalbuminuria among African Americans with Type 2 Diabetes: A 3-Year Study Mohamed G. Atta, MD, MPH, Kesha Baptiste-Roberts,

Repeated Hemoglobin A1C Ordering in the VA Health System

Glycemic Management in ESRD and Earlier Stages of CKD

Molly E. Waring, PhD, Jane S

Impact of Educational Attainment on Health Outcomes in Moderate to Severe CKD Rachael L. Morton, PhD, Iryna Schlackow, DPhil, Natalie Staplin, PhD, Alastair.

Baseline Kidney Function as Predictor of Mortality and Kidney Disease Progression in HIV-Positive Patients Fowzia Ibrahim, MSc, Lisa Hamzah, MRCP, Rachael.

CKD and the Risk of Acute, Community-Acquired Infections Among Older People With Diabetes Mellitus: A Retrospective Cohort Study Using Electronic Health.

Current accepted hemodynamic criteria for critical limb ischemia do not accurately stratify patients at high risk for limb loss Raghuveer Vallabhaneni,

Beef Tea, Vitality, Creatinine, and the Estimated GFR

The Malnourished Heart: An Unusual Case of Heart Failure

Estimated Glomerular Filtration Rate Within the Normal or Mildly Impaired Range and Incident Cardiovascular Disease Alon Eisen, MD, Moshe Hoshen, PhD,

Impact of Diabetes Mellitus on the Association of Vascular Disease Before Transplantation With Long-term Transplant and Patient Outcomes After Kidney.

MATCH Results: Implications for the Internist

Shannon M. Dunlay, MD, MS, Quinn R. Pack, MD, Randal J

Prevalence and Risk Factors for Erectile Dysfunction in the US

Nilay S. Shah, MD, MPH, David Leonard, PhD, Carrie E

Age Differences in Treatment and Control of Hypertension in US Physician Offices, : A Serial Cross-sectional Study Anna Gu, MD, PhD, Yu Yue,

Sodium Intake and Mortality in the NHANES II Follow-up Study

Strategies for Optimizing Glycemic Control and Cardiovascular Prognosis in Patients With Type 2 Diabetes Mellitus James H. O'Keefe, MD, Mohammad Abuannadi,

Diabetes, prediabetes, and cardiovascular risk: Shifting the paradigm

Volume 75, Issue 1, Pages (January 2009)

Sushrut S. Waikar, MD, MPH, Gary C. Curhan, MD, ScD, Steven M

The Association Between Barium Examination and Subsequent Appendicitis: A Nationwide Population-Based Study Hao-Ming Li, MD, Lee-Ren Yeh, MD, Ying-Kai.

Inflammatory Markers and Loss of Muscle Mass (Sarcopenia) and Strength

Falls in Older Adults: Risk Assessment, Management and Prevention

Daniel E. Weiner, MD, MS, Hocine Tighiouart, MS, John L

Jay S. Kaufman, PhD, Sam Harper, PhD The American Journal of Medicine

Effects of structured care by a pharmacist-diabetes specialist team in patients with Type 2 diabetic nephropathy Wilson Y.S. Leung, BPharm, PhD, Wing-Yee.

Jacob J.E. Koopman, MD, PhD American Journal of Kidney Diseases

Presentation transcript:

Periodontal Pocket Depth, Hyperglycemia, and Progression of Chronic Kidney Disease: A Population-Based Longitudinal Study Jia-Feng Chang, MD, Jih-Chen Yeh, DDS, Ya-Lin Chiu, DDS, Jian-Chiun Liou, PhD, Jing-Ru Hsiung, DDS, Tao-Hsin Tung, PhD The American Journal of Medicine Volume 130, Issue 1, Pages 61-69.e1 (January 2017) DOI: 10.1016/j.amjmed.2016.08.024 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 (A) Unadjusted, partially, and fully adjusted hazard ratios (HR) of progression of chronic kidney disease across different categories of periodontal pocket depth in 1486 patients with periodontal diseases and chronic kidney disease during 7621 person-years of follow-up. (Partially adjusted: age, diabetes mellitus, periodontal pocket depth, albumin-to-creatinine ratio. Fully adjusted: age, diabetes mellitus, periodontal pocket depth, albumin-to-creatinine ratio, sex, hypertension, creatinine, smoking, and betel nut chewing.) The lowest hazard ratio group (periodontal pocket depth <3.8 mm) served as the reference group. Patients with higher periodontal pocket depth (>4.5 mm) had the greatest risk of progression of chronic kidney disease after full adjustments. Note that a linearly incremental risk of progression of chronic kidney disease associated with levels of periodontal pocket depth was robust. (B) Kaplan-Meier survival curves of event-free probability among patients with different categories of periodontal pocket depth. CI = confidence interval; PPD = periodontal pocket depth. The American Journal of Medicine 2017 130, 61-69.e1DOI: (10.1016/j.amjmed.2016.08.024) Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 2 (A) Unadjusted, partially, and fully adjusted hazard ratios (HR) of progression of chronic kidney disease across different categories of hemoglobin A1c (HbA1C) in 1486 patients with periodontal diseases and chronic kidney disease during 7621 person-years of follow-up. (Partially adjusted: age, diabetes mellitus, periodontal pocket depth, albumin-to-creatinine ratio. Fully adjusted: age, diabetes mellitus, periodontal pocket depth, albumin-to-creatinine ratio, sex, hypertension, creatinine, smoking, and betel nut chewing.) The lowest hazard ratio group (HbA1C <6.0%) served as the reference group. Patients with higher HbA1C (>6.5%) had the greatest risk of progression of chronic kidney disease after full adjustments. Note that a linearly incremental risk of progression of chronic kidney disease associated with HbA1C levels was robust. (B) Kaplan-Meier survival curves of event-free probability among patients with different categories of HbA1C. CI = confidence interval. The American Journal of Medicine 2017 130, 61-69.e1DOI: (10.1016/j.amjmed.2016.08.024) Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 3 (A) The hazard ratios (HR) of progression of chronic kidney disease (CKD) across different categories of periodontal pocket depth and hemoglobin A1c (HbA1C) in 1486 patients with periodontal diseases and chronic kidney disease during 7621 person-years of follow-up (fully adjusted: age, diabetes mellitus, periodontal pocket depth, albumin-to-creatinine ratio, sex, hypertension, creatinine, smoking, and betel nut chewing). The reference group (periodontal pocket depth [PPD] <3.8 mm and HbA1C <6.0%) had the lowest HR. Patients with higher periodontal pocket depth (>4.5 mm) and higher HbA1C (>6.5%) had the greatest risk of progression of chronic kidney disease after full adjustments. (B) Kaplan-Meier survival curves of event-free probability among patients with different categories of periodontal pocket depth and HbA1C. The American Journal of Medicine 2017 130, 61-69.e1DOI: (10.1016/j.amjmed.2016.08.024) Copyright © 2016 Elsevier Inc. Terms and Conditions

Supplementary Figure (A) Comparison of structures of periodontal tissues in health and disease. (B) Measurement of periodontal pocket depth using a periodontal probe. (C) Illustration of measurement method and pathologic landmarks of periodontal diseases. A = alveolar bone; BP = bottom of the periodontal pocket; C = calculus; CAL = clinical attachment loss; CEJ = cemento-enamel junction; D = destructive alveolar bone; E = epithelium; G = gingival sulcus; GR = gingival recession; H = healthy gingiva; I = inflammatory gingiva; P = periodontal pocket; PPD = periodontal pocket depth; PD = periodontal disease; R = root. The American Journal of Medicine 2017 130, 61-69.e1DOI: (10.1016/j.amjmed.2016.08.024) Copyright © 2016 Elsevier Inc. Terms and Conditions