Low ERCC1 Expression in Malignant Pleural Mesotheliomas Treated with Cisplatin and Vinorelbine Predicts Prolonged Progression-Free Survival Zarah Glad.

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Low ERCC1 Expression in Malignant Pleural Mesotheliomas Treated with Cisplatin and Vinorelbine Predicts Prolonged Progression-Free Survival Zarah Glad Zimling, MD, Jens Benn Sørensen, MD, DmSc, Thomas Alexander Gerds, PhD, Cecilia Bech, MD, Claus Bøgelund Andersen, MD, DMSc, Eric Santoni-Rugiu, MD, PhD Journal of Thoracic Oncology Volume 7, Issue 1, Pages 249-256 (January 2012) DOI: 10.1097/JTO.0b013e318233d6a9 Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 ERCC1 immunoreactions in different representative tissue sections. A, Glioblastoma multiforme with known loss-of-heterozygosity at the 19q locus served as negative control. Note only sporadic positive nuclei. B, Ovarian cancer cell line A2780 served as positive control and showed moderate nuclear staining. C, Lymph node endothelium was used as an intensity reference and assigned an intensity score of 2. D, ERCC1 in normal pleura from a patient with cystic fibrosis showing mild mesothelial hyperplasia with an H-score of 2. E, ERCC1-negative MPM with an H-score of 0.5. F, ERCC1-positive MPM with an H-score of 3. Journal of Thoracic Oncology 2012 7, 249-256DOI: (10.1097/JTO.0b013e318233d6a9) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 A, Kaplan-Meier curves showing overall survival according to ERCC1 status with 95% confidence intervals (CIs) (gray shades), p = 0.37. The number of patients in the study at different time-points is indicated below the figure. B, Kaplan-Meier curves showing progression-free survival probabilities by ERCC1 status with 95% CIs (gray shades), p = 0.053. The numbers of patients at risk are indicated below the figure. Journal of Thoracic Oncology 2012 7, 249-256DOI: (10.1097/JTO.0b013e318233d6a9) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 3 Time-dependent true positive and true negative rates (%) for predicting patient's progression-free survival status based on ERCC1. The true positive rate (TPR) is the probability of a patient being ERCC1 positive given he or she has progressed at time t. The true negative rate (TNR) is the probability of a patient being ERCC1 negative given he or she is progression-free at time t. Journal of Thoracic Oncology 2012 7, 249-256DOI: (10.1097/JTO.0b013e318233d6a9) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions