Tiki Casts a Spell on Wnt

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Tiki Casts a Spell on Wnt Jean-Paul Vincent, Tony Magee Cell Volume 149, Issue 7, Pages 1426-1427 (June 2012) DOI: 10.1016/j.cell.2012.06.007 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 Tiki Is a Transmembrane Protein with an Extracytoplasmic Protease Domain A fraction of Wnt coexpressed with Tiki (represented by a stylized Polynesian head) is secreted in a cleaved (inactive) form. In this configuration, proteolytic cleavage of Wnt presumably occurs both in the secretory pathway (shown in the lower left) as well as at the cell surface (not shown). The ratio of cleaved to uncleaved Wnt likely depends on the relative levels of expression of Tiki and Wnts and also, possibly, on posttranslational regulation of Tiki. Mosaic analysis shows that Tiki presented at the cell surface can also cleave Wnt produced from a neighboring cell (right). Cell 2012 149, 1426-1427DOI: (10.1016/j.cell.2012.06.007) Copyright © 2012 Elsevier Inc. Terms and Conditions