Unveiling the Role of Senescence-Induced Cellular Plasticity

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Presentation transcript:

Unveiling the Role of Senescence-Induced Cellular Plasticity Jumpei Taguchi, Yasuhiro Yamada Cell Stem Cell Volume 20, Issue 3, Pages 293-294 (March 2017) DOI: 10.1016/j.stem.2017.02.001 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 In Vivo Reprogramming Reveals a Link between Cellular Plasticity and Senescence In vivo induction of reprogramming factors triggers two divergent cellular outcomes, cellular reprogramming and damage-induced cellular senescence. Senescence-associated secretory phenotype (SASP), particularly IL-6, promotes in vivo reprogramming, suggesting that SASP enhances cellular plasticity in tissue. These findings could have implications for rejuvenation, tissue regeneration, and cancer development in multicellular organisms. Cell Stem Cell 2017 20, 293-294DOI: (10.1016/j.stem.2017.02.001) Copyright © 2017 Elsevier Inc. Terms and Conditions