Cell Autonomous and Non-Autonomous Effects of Senescent Cells in the Skin  Marco Demaria, Pierre Yves Desprez, Judith Campisi, Michael C. Velarde  Journal of Investigative Dermatology  Volume 135, Issue 7, Pages 1722-1726 (July 2015) DOI: 10.1038/jid.2015.108 Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Senescent cells act in the skin via both cell autonomous and non-autonomous mechanisms. The transient induction of cellular senescence during wound healing promotes granulation tissue formation and tissue remodeling, whereas it prevents the hyperproliferation of potentially premalignant or malignant lesions. In contrast, the accumulation of senescent cells with age causes poor tissue regeneration and loss of homeostasis in the skin. The chronic presence of senescent cells further creates a tissue environment with chronic inflammation promoting collagen degradation, both of which can lead to aging phenotypes in the skin. SASP, senescence-associated secretory phenotype. Journal of Investigative Dermatology 2015 135, 1722-1726DOI: (10.1038/jid.2015.108) Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions