Cardiac cell transplantation: closer to bedside

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Cardiac cell transplantation: closer to bedside Osman O Al-Radi, MBBS, Vivek Rao, MD, PhD, Ren-ke Li, PhD, Terrence Yau, MD, MS, Richard D Weisel, MD The Annals of Thoracic Surgery Volume 75, Issue 2, Pages S674-S677 (February 2003) DOI: 10.1016/S0003-4975(02)04690-8

Fig 1 (A) Bone marrow cells cultured with 10-μL 5-azacytidine (magnification ×200). Bone marrows cells were cultured for 10 days with 5-aza added to the medium only on day 3. Only the cells cultured with 5-aza formed a network of myotubules. Occasional adipocytes were present. (B) Cultured bone marrow cells imuunohistochemically stained for troponin I (magnification ×400). Cultured bone marrow cells were treated with 10 μL 5-aza for 24 hours on day 3 of a 10-day culture. Myotubular cells, but not the other cell types, stained positively for troponin I. The Annals of Thoracic Surgery 2003 75, S674-S677DOI: (10.1016/S0003-4975(02)04690-8)

Fig 2 Representative three-dimensional views of reconstructed hearts from gated Single Photon Emission Tomography with Sestamibi (SPECT–MIBI) scan. Animals in control (a) and transplant (b) groups underwent scanning at 4 weeks after cell transplantation. (a) In control group, end-diastolic volume (EDV) was 82 mL, end-systolic volume (ESV) was 52 mL, and ejection fraction (EF) was 37%. (b) In transplant group, end-diastolic volume was 72 mL, end-systolic volume was 40 mL, and ejection fraction was 50%. The Annals of Thoracic Surgery 2003 75, S674-S677DOI: (10.1016/S0003-4975(02)04690-8)