Lipiodol alters murine uterine dendritic cell populations: A potential mechanism for the fertility-enhancing effect of lipiodol Neil Phillip Johnson,

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Lipiodol alters murine uterine dendritic cell populations: A potential mechanism for the fertility-enhancing effect of lipiodol Neil Phillip Johnson, Santwona Bhattu, B.Sc.Hon., Angela Wagner, B.Sc.Hon., Deborah Adella Blake, Ph.D., Lawrence William Chamley, Ph.D. Fertility and Sterility Volume 83, Issue 6, Pages 1814-1821 (June 2005) DOI: 10.1016/j.fertnstert.2004.11.065 Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions

FIGURE 1 Mean number of F4/80+ macrophages per square millimeter of endometrium in the three treatment groups of mice. Error bars represent the standard error of the mean. Johnson. Lipiodol and fertility. Fertil Steril 2005. Fertility and Sterility 2005 83, 1814-1821DOI: (10.1016/j.fertnstert.2004.11.065) Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions

FIGURE 2 Mean number of CD205+ dendritic cells per square millimeter of uterus from the three treatment groups of mice. Error bars represent the standard error of the mean. *Mean number of CD205+ dendritic cells in lipiodol-treated mice is significantly lower than in sham-treated mice (P=.007) and saline-treated mice (P<.05). Johnson. Lipiodol and fertility. Fertil Steril 2005. Fertility and Sterility 2005 83, 1814-1821DOI: (10.1016/j.fertnstert.2004.11.065) Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions

FIGURE 3 Shows the distribution of CD205+ dendritic cells associated with uterine structures from the sham-treated (blue), saline-treated (beige) and lipiodol-treated (red) mice. Error bars represent the standard error of the mean. Following lipiodol treatment, there were significantly fewer CD205+ dendritic cells near the glandular epithelium and luminal epithelium in comparison to the sham-treated and saline-treated groups (*P<.05). There were no significant differences in the distribution of dendritic cells between the three treatment groups in the myometrium, serosa or near the blood vessels (P>.05). Johnson. Lipiodol and fertility. Fertil Steril 2005. Fertility and Sterility 2005 83, 1814-1821DOI: (10.1016/j.fertnstert.2004.11.065) Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions

FIGURE 4 Mean number of CD1+ dendritic cells per square millimeter of uterus from sham-treated, saline-treated, and lipiodol-treated animals. Error bars represent the standard error of the mean. *Mean number of CD1+ dendritic cells in lipiodol-treated mice is significantly higher than sham-treated mice (P=.01). Johnson. Lipiodol and fertility. Fertil Steril 2005. Fertility and Sterility 2005 83, 1814-1821DOI: (10.1016/j.fertnstert.2004.11.065) Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions

FIGURE 5 Shows the distribution of CD1+ dendritic cells associated with uterine structures from the sham-treated (blue), saline-treated (beige) and lipiodol-treated (red) mice. Error bars represent the standard error of the mean. Following lipiodol treatment, there were significantly more CD1+ dendritic cells near the glandular epithelium and in the stroma in comparison to the sham-treated and saline-treated groups (*P<.05). There were no significant differences in the distribution of CD1+ dendritic cells in the myometrium, serosa or near the blood vessels and in the luminal epithelium between the treatment groups (P>.05). Johnson. Lipiodol and fertility. Fertil Steril 2005. Fertility and Sterility 2005 83, 1814-1821DOI: (10.1016/j.fertnstert.2004.11.065) Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions