IL-17A Has Some Nerve! Immunity

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IL-17A Has Some Nerve! Immunity James A. Sanford, Richard L. Gallo  Immunity  Volume 43, Issue 3, Pages 414-415 (September 2015) DOI: 10.1016/j.immuni.2015.08.025 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Candida albicans Stimulate IL-17A Production through Sensory Neuron Activation Cutaneous nociceptor sensory neurons detect invading Candida albicans, resulting in the release of the neuropeptide calcitonin gene-related peptide (CGRP). CGRP stimulates CD301b+ dermal dendritic cells (dDCs) to produce IL-23, which in turn activates skin-resident γδ T cells to secrete IL-17A, an important cytokine mediating antifungal defenses in the skin. AMPs, antimicrobial peptides. Immunity 2015 43, 414-415DOI: (10.1016/j.immuni.2015.08.025) Copyright © 2015 Elsevier Inc. Terms and Conditions

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