GroEL: More than Just a Folding Cage

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GroEL: More than Just a Folding Cage Sheena E. Radford Cell Volume 125, Issue 5, Pages 831-833 (June 2006) DOI: 10.1016/j.cell.2006.05.021 Copyright © 2006 Elsevier Inc. Terms and Conditions

Figure 1 Altering the Size or Charge of the GroEL Folding Cavity Can Have a Profound Influence on Protein Folding (Left) Wild-type GroEL/GroES with a folding substrate (green) is shown. (Middle) Changing the cavity size by deleting or replicating the motifs at the C terminus of each GroEL subunit affects substrate folding. (Right) Alteration of the surface charge of the cavity in a version of GroEL (named SR1) that contains only a single ring can also affect the folding of some substrates. Cell 2006 125, 831-833DOI: (10.1016/j.cell.2006.05.021) Copyright © 2006 Elsevier Inc. Terms and Conditions