To Cut or Not to Cut: Discovery of a Novel Regulator of DNA Break Resection  James M. Daley, Patrick Sung  Molecular Cell  Volume 61, Issue 3, Pages 325-326 (February 2016) DOI: 10.1016/j.molcel.2016.01.022 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Potential Models for Inhibition of Resection by HELB (A) Model in which HELB is recruited to RPA-coated ssDNA behind the resection machinery. In this situation, 5′ to 3′ translocation would lead HELB away from the nuclease ensemble. “B” indicates BLM, “H” indicates HELB, and the yellow pacman indicates EXO1 or DNA2. (B) Model in which HELB is recruited to the 5′ flap after unwinding but before strand cleavage, thus positioning it to translocate toward BLM and its associated nucleases. Molecular Cell 2016 61, 325-326DOI: (10.1016/j.molcel.2016.01.022) Copyright © 2016 Elsevier Inc. Terms and Conditions