Craig Mowat, Andrew Carswell, Angela Wirz, Kenneth E.L. McColl

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Omeprazole and dietary nitrate independently affect levels of vitamin C and nitrite in gastric juice Craig Mowat, Andrew Carswell, Angela Wirz, Kenneth E.L. McColl Gastroenterology Volume 116, Issue 4, Pages 813-822 (April 1999) DOI: 10.1016/S0016-5085(99)70064-8 Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 1 Effect of standard nitrate meal on serum nitrate, saliva nitrite, gastric nitrite, gastric TVC, and gastric AA levels in all 20 subjects before omeprazole therapy. An intragastric bolus of 20 mmol nitrate in 50 mL of H2O was introduced immediately after baseline (time 0) collections. Values are medians plus interquartile ranges. *P < 0.05, **P < 0.001, ***P < 0.01 compared with values at time 0. Gastroenterology 1999 116, 813-822DOI: (10.1016/S0016-5085(99)70064-8) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 2 Effect of omeprazole on fasting gastric nitrite, fasting gastric AA, and gastric nitrite levels 60 minutes after intragastric administration of 20 mmol nitrate in 50 mL of H2O. Results for all 20 subjects are included. Gastroenterology 1999 116, 813-822DOI: (10.1016/S0016-5085(99)70064-8) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 3 Effect of standard nitrate meal, in the presence of omeprazole-induced hypochlorhydria, on serum nitrate, saliva nitrite, gastric nitrite, gastric TVC, and gastric AA in all 20 subjects. An intragastric bolus of 20 mmol nitrate in 50 mL of H2O was introduced immediately after baseline (time 0) collections. Values are medians plus interquartile ranges. *P < 0.05 compared with values at time 0. Gastroenterology 1999 116, 813-822DOI: (10.1016/S0016-5085(99)70064-8) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 4 Effect of standard nitrate meal on gastric TVC levels in 9 H. pylori–positive and 11 H. pylori–negative subjects before (●) and during (●) omeprazole treatment. An intragastric bolus of 20 mmol nitrate in 50 mL of H2O was introduced immediately after baseline (time 0) collections. Values are medians plus interquartile ranges. *P < 0.02; significantly lower than corresponding preomeprazole values. Gastroenterology 1999 116, 813-822DOI: (10.1016/S0016-5085(99)70064-8) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 5 Effect of 4 weeks of treatment with omeprazole, 40 mg daily, on fasting serum TVC levels in 9 H. pylori–positive and 11 H. pylori–negative subjects. Gastroenterology 1999 116, 813-822DOI: (10.1016/S0016-5085(99)70064-8) Copyright © 1999 American Gastroenterological Association Terms and Conditions