Y. Zhao, S. Rennie, J.D. Tucker

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Presentation transcript:

Y. Zhao, S. Rennie, J.D. Tucker Stakeholder Engagement for HIV Clinical Trials: A Systematic Review of the Evidence S. Day, M. Blumberg, T. Vu, Y. Zhao, S. Rennie, J.D. Tucker 22nd International AIDS Conference (AIDS 2018) Amsterdam, Netherlands PURPOSE: To describe stakeholder engagement for informing HIV clinical trials, and compare it to recommendations established by the UNAIDS/AVAC Good Participatory Practice guidelines.

MATERIALS & METHODS Searched 4 databases and 6 HIV/AIDS journals, supplemented by handsearching and expert input. Two reviewers independently assessed titles, abstracts and full-texts. Inclusion criteria: studies describing stakeholder engagement for an HIV clinical trial (behavioral or biomedical; prevention or treatment). Data extracted: Location of engagement Stakeholder types Engagement method Purpose of engagement

RESULTS: 108 studies included in review More studies (44.4%) conducted engagement in high-income countries (27.8% middle- & 8.3% low-income; 19.5% mixed/unspecified locations). The most frequently used engagement methods were researcher- driven: interviews (39.8%) & focus groups (30.6%). Studies engaged 35 different types of stakeholders: not only HIV-affected community members, but also broader stakeholders. Data analysis revealed that more engagement was conducted to inform early rather than later trial processes. More Engagement Less Engagement

CONCLUSIONS More resources may be needed to support stakeholder engagement in low- and middle-income countries. Future research should consider engagement methods that are more participatory and stakeholder-driven. More research is needed on barriers and facilitators to involving stakeholders in the later stages of HIV trials. Acknowledgements All members of the searcHIV team 2BeatHIV for use of images National Institutes of Health (NIAID R01A108366, 5P30AI050410)