Brain Fraction and SPM Normalized Penumbra MSmcDESPOT Brain Fraction and SPM Normalized Penumbra

Updated EDSS

Updated EDSS

Updated EDSS

Updated EDSS This is with DAWM defined by SPM penumbra in WM containing lesion cores. Overall SPM significantly shrunk the DAWM selection by about order of 10 in vol.

Brain Fraction with Prelim. GM Similar to what was seen in Nov.

MWF Std. Dev. In Normals 0–0.11 scale Clearly there is high variation in the GM, most likely due to registration imperfections Similarly at edges of ventricles

FLAIR Std. Dev. In Normals – Raw Scale 0–50, not too relevant here since not quantitative Inhomogeneity variation across normals caused a higher degree of fluctuation in the forebrain

FLAIR Std. Dev. In Normals – Max Normalized Not sure how to window properly so that the std. dev. maps are comparable Wanted to see the image get darker -> lower std. dev. -> tighter distribution Again the forebrain has higher variability

FLAIR Std. Dev. In Normals – SPM Normalized 0–50, same scale as Raw Removes forebrain variability artifact However, the image did not darken vs. Raw so the distribution did not get tighter

FLAIR Std. Dev. In Normals – SPM Normalized This is auto-windowed to the “robust range” as the max normalized one was also Only very slight brightening vs. 0-50 range Interpretation: Max normalized seems to achieve a lower standard deviation across normals, this is confirmed by the larger DAWM selection