Technology requirements for preimplantation genetic diagnosis to improve assisted reproduction outcomes  Santiago Munné, Ph.D., Dagan Wells, Ph.D., Jacques Cohen, Ph.D.  Fertility and Sterility  Volume 94, Issue 2, Pages 408-430 (July 2010) DOI: 10.1016/j.fertnstert.2009.02.091 Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

Figure 1 No result rescue (NRR). No result rescue (NRR) as described by Colls et al. (17) can be used to resolve a dubious result. For example, the nucleus on the left image has three signals for chromosome 21 (in green), of which, two are close together. This may represent either two chromosome 21s, one of them with a split signal, or three different chromosomes. By reanalyzing the same nucleus (right image) with a different probe (a subtelomeric one, in red), the doubt is resolved because only two chromosomes are now visible in this locus, indicating that the problem in the left image was due to a split signal. Fertility and Sterility 2010 94, 408-430DOI: (10.1016/j.fertnstert.2009.02.091) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Relationship between implantation rate and error rate. Error rate assuming false-positive error rate = false-negative error rate, so, for example, for a false error rate of 0.1, the total error rate is 0.2. Based on data from Colls et al. (17) and the analysis of Appendix 1. Fertility and Sterility 2010 94, 408-430DOI: (10.1016/j.fertnstert.2009.02.091) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions