Genetic and histologic evidence for autophagy in asthma pathogenesis

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Presentation transcript:

Genetic and histologic evidence for autophagy in asthma pathogenesis Audrey H. Poon, PhD, Fazila Chouiali, MSc, Sze Man Tse, MDCM, Augusto A. Litonjua, MD, MPH, Sabah N.A. Hussain, MD, PhD, Carolyn J. Baglole, PhD, David H. Eidelman, MD, Ronald Olivenstein, MD, James G. Martin, MD, DSc, Scott T. Weiss, MD, MS, Qutayba Hamid, MD, PhD, Catherine Laprise, PhD Journal of Allergy and Clinical Immunology Volume 129, Issue 2, Pages 569-571 (February 2012) DOI: 10.1016/j.jaci.2011.09.035 Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 A double-membrane autophagosome was detected in a fibroblast from a bronchial biopsy tissue sample of a patient with moderate asthma. Tissue was viewed at magnifications of ×1,480 (A), ×16,100 (B), and ×62,200 (C). Boxed areas were viewed at higher magnification in subsequent illustrations. An arrow indicates an autophagosome. A corresponding fibroblast from a healthy subject was viewed at magnifications of ×4,030 (D), ×16,100 (E), and ×37,000 (F), respectively. Journal of Allergy and Clinical Immunology 2012 129, 569-571DOI: (10.1016/j.jaci.2011.09.035) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Autophagosomes were detected in bronchial epithelial cells from a patient with moderate asthma. Tissue was viewed at magnifications of ×4030 (A), ×9760 (B), and ×37,000 (C), respectively. Corresponding epithelial cells of a healthy subject were viewed at magnifications of ×6,390 (D), ×16,100 (E), and ×37,000 (F), respectively. Arrows indicate double-membrane autophagosomes. Journal of Allergy and Clinical Immunology 2012 129, 569-571DOI: (10.1016/j.jaci.2011.09.035) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions