INT-767 treatment prevents renal lipid accumulation in diabetic DBA/2J mice. INT-767 treatment prevents renal lipid accumulation in diabetic DBA/2J mice.

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INT-767 treatment prevents renal lipid accumulation in diabetic DBA/2J mice. INT-767 treatment prevents renal lipid accumulation in diabetic DBA/2J mice. (A) Oil red O staining of kidney sections. (B) Kidney lipid content analysis indicating increased triglyceride and cholesterol accumulation in diabetic DBA/2J kidneys, which is prevented by INT-767 treatment. CON, nondiabetic DBA/2J; STZ, diabetic DBA/2J without treatment; STZ/INT-767, diabetic DBA/2J treated with INT-767. Scale bar, 50 μm. *P<0.05 versus CON (n=6 mice per group); †P<0.05 versus STZ (n=6 mice per group). Xiaoxin X. Wang et al. JASN 2018;29:118-137 ©2018 by American Society of Nephrology