The least of 3 evils: Exposure to red blood cell transfusion, anemia, or both? Gabriel Loor, MD, Jeevanantham Rajeswaran, PhD, Liang Li, PhD, Joseph F.

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Presentation transcript:

The least of 3 evils: Exposure to red blood cell transfusion, anemia, or both? Gabriel Loor, MD, Jeevanantham Rajeswaran, PhD, Liang Li, PhD, Joseph F. Sabik, MD, Eugene H. Blackstone, MD, Keith R. McCrae, MD, Colleen G. Koch, MD, MS, MBA The Journal of Thoracic and Cardiovascular Surgery Volume 146, Issue 6, Pages 1480-1487.e6 (December 2013) DOI: 10.1016/j.jtcvs.2013.06.033 Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Histogram showing relationship between intraoperative nadir hematocrit (HCT) and intraoperative red blood cell (RBC) transfusion status. The Journal of Thoracic and Cardiovascular Surgery 2013 146, 1480-1487.e6DOI: (10.1016/j.jtcvs.2013.06.033) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 A-D, Relationship among anemia and transfusion exposure groups and outcomes. eGFR, Estimated glomerular filtration rate; HCT, hematocrit; RBC, red blood cell; LOS, length of stay. The Journal of Thoracic and Cardiovascular Surgery 2013 146, 1480-1487.e6DOI: (10.1016/j.jtcvs.2013.06.033) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 A-D, Relative effect size stratified by intraoperative red blood cell (RBC) transfusion and intraoperative nadir hematocrit (HCT). eGFR, Estimated glomerular filtration rate; LOS, length of stay. The Journal of Thoracic and Cardiovascular Surgery 2013 146, 1480-1487.e6DOI: (10.1016/j.jtcvs.2013.06.033) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Survival after cardiac surgery stratified by intraoperative nadir hematocrit (HCT) and intraoperative red blood cell (RBC) transfusion exposure groups. Vertical bars, confidence limits equivalent to ±1 SE; solid lines enclosed within dashed 68% confidence bands, parametric estimates. Numbers of patients remaining at risk appear below the horizontal axis. The Journal of Thoracic and Cardiovascular Surgery 2013 146, 1480-1487.e6DOI: (10.1016/j.jtcvs.2013.06.033) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure E1 CONSORT-style diagram of patient population. The 4 groups analyzed are color coded as in manuscript Figures 1 through 4. CPB, Cardiopulmonary bypass; HCT, hematocrit; Intra-op, intraoperative; post-op, postoperative. The Journal of Thoracic and Cardiovascular Surgery 2013 146, 1480-1487.e6DOI: (10.1016/j.jtcvs.2013.06.033) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions