Diagrammatic representation of syringomyelia and the “presyrinx” hypothesis in the setting of obstruction to CSF flow. Diagrammatic representation of syringomyelia.

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Barak Bar M.D. UCSF Department of Neurology
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Presentation transcript:

Diagrammatic representation of syringomyelia and the “presyrinx” hypothesis in the setting of obstruction to CSF flow. Diagrammatic representation of syringomyelia and the “presyrinx” hypothesis in the setting of obstruction to CSF flow. A, Sagittal view of the craniocervical junction in a patient with a Chiari I malformation shows abnormal descent of the cerebellar tonsil below the level of the foramen magnum (arrow). A segment of spinal cord parenchyma (box) is magnified in B to D, which represent views of CSF dynamics at the level of the spinal cord parenchyma in the presence of alterations in normal CSF flow and variable patency of the central canal. B, Focal noncommunicating syrinx. In the setting of a Chiari I malformation and a variably stenotic central canal (which is a normal variant in many adults), as the tonsils descend rapidly during systole, CSF is driven into the spinal cord parenchyma by increased CSF pressure (thick vertical arrow). Net CSF flow occurs toward the central canal, resulting in focal syringomyelia, which is limited in its craniocaudal extent by intervening stenosis of the central canal. CC = central canal, A = arachnoid, P = pia, SAS = subarachnoid space, PVS = perivascular space. C, Extensive noncommunicating syrinx. This situation is similar to B, but the central canal is more extensively patent. In this situation, a long-segment dilatation of the central canal occurs as CSF is driven into the central canal (curved arrows) via the perivascular spaces by the accentuated CSF pulse pressure (thick vertical arrow) that results from the downward motion of the low-lying cerebellar tonsils in systole. D, “Presyrinx.” In the setting of altered CSF flow, as with a Chiari I malformation, fluid in the subarachnoid space is subjected to increased pressure (thick vertical arrow). Net CSF flow is into the spinal cord parenchyma; however, because the central canal is not patent (as indicated by the horizontal lines), fluid cannot accumulate within the central canal (curved arrows) and, therefore, diffuses through the cord parenchyma (stippled area), resulting in cord enlargement and edema. Nancy J. Fischbein et al. AJNR Am J Neuroradiol 1999;20:7-20 ©1999 by American Society of Neuroradiology