Volume 61, Issue 6, Pages (June 2002)

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Presentation transcript:

Volume 61, Issue 6, Pages 2149-2156 (June 2002) Activity and functional significance of the renal kallikrein-kinin-system in polycystic kidney disease of the rat Claude Braun, Thomas Kleemann, Ulrich Hilgenfeldt, Udo Riester, Peter Rohmeiss, Fokko J. Van Der Woude Kidney International Volume 61, Issue 6, Pages 2149-2156 (June 2002) DOI: 10.1046/j.1523-1755.2002.00385.x Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 1 Effect of treatment with 2 mg/kg/day ramipril, 10 mg/kg/day HR 720, 2 × 200 μg SC HOE 140, or des-Arg9-BK for four days on systolic blood pressure in 3- and 9-month-old non-affected controls (SD) and polycystic kidney disease (PKD) rats (N = 10, each group). Symbols are: (□) 9-month-old PKD; (▵) 9-month-old SD; (○) 3-month-old PKD; (⋄) 3-month-old SD. Systolic blood pressure was significantly reduced in 9-month-old PKD and SD after treatment with ramipril and HR 720 (*P < 0.05). Data are presented as means ± SEM. Kidney International 2002 61, 2149-2156DOI: (10.1046/j.1523-1755.2002.00385.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 2 Effects of treatment with 2 mg/kg/day ramipril, 10 mg/kg/day HR 720, 2 × 200 μg SC HOE 140, or des-Arg9-BK for four days on proteinuria in 3- and 9-month-old SD and PKD rats (N = 10, each group). Symbols are: (□) 9-month-old PKD; (▵) 9-month-old SD; (○) 3-month-old PKD; (⋄) 3-month-old SD. Proteinuria was significantly reduced in 3- and 9-month-old PKD after treatment with ramipril and HOE 140 (*P < 0.05). Data are presented as means ± SEM. Kidney International 2002 61, 2149-2156DOI: (10.1046/j.1523-1755.2002.00385.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 3 Effect of treatment with 2 mg/kg/day ramipril, 10 mg/kg/day HR 720, 2 × 200 μg SC HOE 140, or des-Arg9-BK for four days on albuminuria in 3- and 9-month-old SD and PKD rats (N = 10, each group). Symbols are: (□) 9-month-old PKD; (▵) 9-month-old SD; (○) 3-month-old PKD; (⋄) 3-month-old SD. Albuminuria was significantly reduced in 3-and 9-month-old PKD after treatment with ramipril and HOE 140 (*P < 0.05). Data are presented as means ± SEM. Kidney International 2002 61, 2149-2156DOI: (10.1046/j.1523-1755.2002.00385.x) Copyright © 2002 International Society of Nephrology Terms and Conditions