Figure 2 Temporal summation

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Figure 2 Temporal summation Figure 2 | Temporal summation. During quantitative sensory testing, the perception of pain intensity assessed with a visual analogue scale (VAS) in response to a repetitive thermal stimulation of uniform intensity applied to the forearm will gradually increase owing to central sensitization. In a patient with chronic pain, central sensitization facilitates temporal summation, whereas, in a healthy person, this intensity does not increase owing to habituation to the stimulus. Modified with permission obtained from Springer © Arendt-Nielsen, L. Handb. Exp. Pharmacol. 227, 79–102 (2015). Modified with permission obtained from Springer © Arendt–Nielsen, L. Handb. Exp. Pharmacol. 227, 79–102 (2015). Reynolds, W. S. et. al. (2016) Does central sensitization help explain idiopathic overactive bladder? Nat. Rev. Urol. doi:10.1038/nrurol.2016.95