Preferential infection of CD1c+ DCs by HIV-1, HIV-2, and influenza virus. Preferential infection of CD1c+ DCs by HIV-1, HIV-2, and influenza virus. (A)

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Preferential infection of CD1c+ DCs by HIV-1, HIV-2, and influenza virus. Preferential infection of CD1c+ DCs by HIV-1, HIV-2, and influenza virus. (A) Absolute cell number of sorted DC subsets (n = 25 donors). Total DCs were enriched by negative selection with magnetic beads (input) and sorted by fluorescence-activated cell sorting (FACS). (B) Susceptibility of blood DCs to infection by HIV-2. GFP expression in blood DC subsets that were sorted and infected for 48 hours with GFP-coding HIV-2(JK) at a multiplicity of infection (MOI)GHOST X4R5 = 0.4. (C) Quantification as in (B) (n = 14 independent donors combined from seven independent experiments). (D) Susceptibility of blood DCs to infection by HIV-1 and impact of codelivered Vpx protein that degrades SAMHD1. GFP expression in blood DC subsets that were sorted and infected for 48 hours with GFP-coding HIV-1(BaL) (MOI = 0.8), HIV-1(BaL) Vpx (MOI = 0.4), HIV-1(NL4-3) (MOI = 0.6), or HIV-1(NL4-3) (MOI = 0.3). Viruses were not spinoculated in this experiment. (E) Quantification as in (D) (n = 4 independent donors combined from two independent experiments). Viruses were not spinoculated in this experiment. (F) Susceptibility of blood DCs to infection by influenza virus. GFP expression in sorted CD1c+ and CD141+ DCs pulsed with NS1-GFP H1N1 influenza virus [GFP-tagged FluA(PR8); MOI = 2] for 1 hour. Analysis was performed 4 hours after infection. (G) Quantification as in (F) in DCs at 24 hours after infection (n = 8; seven donors combined from seven independent experiments, including one donor repeated two times; analysis of variance). FSC, forward scatter. ***P < 0.001, ****P < 0.0001. Aymeric Silvin et al. Sci. Immunol. 2017;2:eaai8071 Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works