Effect of haemodilution, acidosis, and hypothermia on the activity of recombinant factor VIIa (NovoSeven®) D. Viuff, B. Lauritzen, A.E. Pusateri, S.

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Effect of haemodilution, acidosis, and hypothermia on the activity of recombinant factor VIIa (NovoSeven®) D. Viuff, B. Lauritzen, A.E. Pusateri, S. Andersen, R. Rojkjaer, P.I. Johansson British Journal of Anaesthesia Volume 101, Issue 3, Pages 324-331 (September 2008) DOI: 10.1093/bja/aen175 Copyright © 2008 The Author(s) Terms and Conditions

Fig 1 Primary bleeding time (BT) in rabbits haemodiluted with 60% HES600 (MW=600 000) or HES200 (MW=200 000) treated with vehicle or with 5 mg kg−1 rFVIIa 5 min after induction of bleeding. Observation period was 3600 s. Baseline represents BT in the same rabbits from the contralateral paw before haemodilution with an observation period of 900 s. Lines within the graph represent medians. British Journal of Anaesthesia 2008 101, 324-331DOI: (10.1093/bja/aen175) Copyright © 2008 The Author(s) Terms and Conditions