Mark Wengrovitz, MD. , Lulseged G. Selassie, MD. , Robert R. M

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Presentation transcript:

Cyclosporine inhibits the development of medial thickening after experimental arterial injury Mark Wengrovitz, MD *, Lulseged G. Selassie, MD **, Robert R.M. Gifford, MD *, Brian L. Thiele, MD * Journal of Vascular Surgery Volume 12, Issue 1, Pages 1-7 (July 1990) DOI: 10.1016/0741-5214(90)90359-I Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Noninjured arteries show normal endothelial monolayer (e), which is denuded (d) 1 day after injury. Note medial smooth muscle cell edema (m) also present 1 day after injury. (Hematoxylin-eosin stain, × 400.) Journal of Vascular Surgery 1990 12, 1-7DOI: (10.1016/0741-5214(90)90359-I) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Medial thickening (t) of injured arteries is prominent at 7 and 14 days, with increased numbers of smooth muscle cell nuclei. Smooth muscle cells (c) are present on luminal side of internal elastic lamina (i) at 28 and 42 days. (Hematoxylin-eosin stain, × 400.) Journal of Vascular Surgery 1990 12, 1-7DOI: (10.1016/0741-5214(90)90359-I) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 3 Suppression (s) of medial thickening (t) is shown in injured artery treated with CYA for 14 days. (Hematoxylin-eosin stain, × 400.) Journal of Vascular Surgery 1990 12, 1-7DOI: (10.1016/0741-5214(90)90359-I) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 4 Suppression (s) of medial thickening (t) is shown in injured arteries treated with CYA. Smooth muscle cells (v) are not seen in treated arteries on the luminal side of the internal elastic lamina (i). (Hematoxylin-eosin stain, × 400.) Journal of Vascular Surgery 1990 12, 1-7DOI: (10.1016/0741-5214(90)90359-I) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions