Volume 154, Issue 5, Pages (April 2018)

Slides:

Advertisements

Similar presentations

Volume 138, Issue 1, Pages e1 (January 2010)

Advertisements

Volume 154, Issue 4, Pages (March 2018)

Flavia D. Mendes, Ayako Suzuki, Schuyler O. Sanderson, Keith D

Volume 144, Issue 2, Pages e2 (February 2013)

Les Lang Gastroenterology Volume 133, Issue 1, (July 2007)

Volume 148, Issue 1, Pages e2 (January 2015)

Volume 146, Issue 2, Pages e3 (February 2014)

Les Lang Gastroenterology Volume 133, Issue 1, (July 2007)

Volume 150, Issue 1, Pages (January 2016)

Christoph Lübbert, Babett Holler Gastroenterology

Evaluation and Management of End-Stage Liver Disease in Children

Cost-Effectiveness of Access Expansion to Treatment of Hepatitis C Virus Infection Through Primary Care Providers Thilo Rattay, Ian P. Dumont, Hauke.

Volume 144, Issue 5, Pages (May 2013)

Volume 137, Issue 5, Pages e2 (November 2009)

Covering the Cover Gastroenterology

Accuracy of Spleen Stiffness Measurement in Detection of Esophageal Varices in Patients With Chronic Liver Disease: Systematic Review and Meta-analysis

Outcomes Among Living Liver Donors

Unusual Cause of Elevated Liver Enzymes in a Female Patient

Volume 140, Issue 7, Pages (June 2011)

Ira J. Fox, Stephen C. Strom Gastroenterology

Supersonic Shear Imaging and Transient Elastography With the XL Probe Accurately Detect Fibrosis in Overweight or Obese Patients With Chronic Liver Disease

Stephen A. Harrison, MD, FACP Clinical Gastroenterology and Hepatology

Volume 154, Issue 5, Pages (April 2018)

A Historical Perspective on Clinical Advances in Pancreatic Diseases

Volume 150, Issue 4, Pages (April 2016)

Accuracy of the ALFSG Index as a Triage Marker in Acute Liver Failure

Volume 154, Issue 4, Pages e7 (March 2018)

Volume 140, Issue 7, Pages e3 (June 2011)

Volume 134, Issue 4, Pages e8 (April 2008)

Volume 155, Issue 4, Pages e3 (October 2018)

Volume 146, Issue 4, Pages e6 (April 2014)

Magnetic Resonance vs Transient Elastography Analysis of Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review and Pooled Analysis of Individual.

Volume 150, Issue 3, Pages e7 (March 2016)

Volume 150, Issue 5, Pages (May 2016)

Volume 138, Issue 1, Pages e1 (January 2010)

Volume 155, Issue 6, Pages (December 2018)

Cost Effectiveness of Universal Screening for Hepatitis C Virus Infection in the Era of Direct-Acting, Pangenotypic Treatment Regimens Mark H. Eckman,

A Scoring System to Predict Readmission of Patients With Acute Pancreatitis to the Hospital Within Thirty Days of Discharge Tom L. Whitlock, April Tignor,

Volume 136, Issue 1, Pages (January 2009)

Volume 150, Issue 3, Pages (March 2016)

Volume 133, Issue 2, Pages (August 2007)

Correlation of FIBROSpect II With Histologic and Morphometric Evaluation of Liver Fibrosis in Chronic Hepatitis C Keyur Patel, David R. Nelson, Don C.

Volume 132, Issue 2, (February 2007)

Ashwin N. Ananthakrishnan, David Lieberman Gastroenterology

Volume 148, Issue 3, Pages (March 2015)

Antoine Debourdeau, Anne Bozon, Romain Altwegg Gastroenterology

Volume 149, Issue 6, Pages (November 2015)

Issue Highlights Clinical Gastroenterology and Hepatology

Volume 155, Issue 5, Pages e5 (November 2018)

Accuracy of Spleen Stiffness Measurement in Detection of Esophageal Varices in Patients With Chronic Liver Disease: Systematic Review and Meta-analysis

Volume 140, Issue 6, Pages e2 (May 2011)

The Dawning of a New Editorial Board for Gastroenterology

Secondary Prophylaxis of Hepatic Encephalopathy: An Open-Label Randomized Controlled Trial of Lactulose Versus Placebo Barjesh Chander Sharma, Praveen.

Volume 151, Issue 4, Pages (October 2016)

Baby-Epsilon Steps Toward the Triple Aim

Covering the Cover Gastroenterology

Issue Highlights Clinical Gastroenterology and Hepatology

Volume 142, Issue 6, Pages e4 (May 2012)

Laurent Castera, Mireen Friedrich-Rust, Rohit Loomba Gastroenterology

An Unusual Cause of Perianal Ulceration in an HIV-Negative Patient

Michelle Maria Pietzak Gastroenterology

Volume 155, Issue 6, Pages (December 2018)

Volume 139, Issue 6, Pages e1 (December 2010)

Reply Gastroenterology

Volume 131, Issue 4, Pages (October 2006)

End-Stage Liver Disease in 2008: Finally a Glass Half Full

The Nobel Pancreas: A Historical Perspective

A Rare Primary Liver Tumor That Responded to Sorafenib

Controversies in Liver Transplantation for Hepatitis C

Volume 135, Issue 5, Pages (November 2008)

Presentation transcript:

Volume 154, Issue 5, Pages 1369-1379 (April 2018) Accuracy of the Enhanced Liver Fibrosis Test vs FibroTest, Elastography, and Indirect Markers in Detection of Advanced Fibrosis in Patients With Alcoholic Liver Disease Maja Thiele, Bjørn Stæhr Madsen, Janne Fuglsang Hansen, Sönke Detlefsen, Steen Antonsen, Aleksander Krag Gastroenterology Volume 154, Issue 5, Pages 1369-1379 (April 2018) DOI: 10.1053/j.gastro.2018.01.005 Copyright © 2018 AGA Institute Terms and Conditions

Gastroenterology 2018 154, 1369-1379DOI: (10. 1053/j. gastro. 2018. 01 Copyright © 2018 AGA Institute Terms and Conditions

Figure 1 Distribution according to Kleiner fibrosis stage of (A) ELF test, (B) FibroTest, and (C) TE. The red horizontal lines represent cutoffs at 10.5 for ELF, 0.58 for FibroTest, and 15 kPa for TE. With AUROC curves for (D) ELF, (E) FibroTest, and (F) TE. Gastroenterology 2018 154, 1369-1379DOI: (10.1053/j.gastro.2018.01.005) Copyright © 2018 AGA Institute Terms and Conditions

Figure 2 Calibration slopes for ELF, FibroTest, and TE. The upper graphs (maroon lines) represent the overall study cohort, the lower graphs (blue lines and red lines) represent the primary and secondary care patients. Calibration slopes graph the agreement between predicted probability of advanced fibrosis on the x-axis and observed proportion with advanced fibrosis on the y-axis. The black dashed line represents perfect calibration, with 100% agreement. The histograms show the number of actual patients with advanced fibrosis (above the line) and number of patients without (below the line) according to the predicted probabilities on the x-axis. Calibration slopes for the six indirect fibrosis indices and for 2D-SWE and TE in intention-to-diagnose can be seen in Supplementary Figures 2 and 3. Gastroenterology 2018 154, 1369-1379DOI: (10.1053/j.gastro.2018.01.005) Copyright © 2018 AGA Institute Terms and Conditions

Figure 3 Correlation between ELF and TE measurements. The black dots represent correct classifications with the ELF test. The red dots represent ELF false positives (to the right of the vertical 10.5 cutoff line). Of 21 false positives with ELF, 14 were true negative with TE (below the horizontal 15 kPa line). The blue dots represent ELF false negatives (left of the 10.5 line). Of 14 false negatives with ELF, 9 were true positive with TE (above the 15-kPa line). Gastroenterology 2018 154, 1369-1379DOI: (10.1053/j.gastro.2018.01.005) Copyright © 2018 AGA Institute Terms and Conditions