Time to Relax: Mechanical Stress Release Guides Stem Cell Responses Sven D. Sommerfeld, Jennifer H. Elisseeff  Cell Stem Cell  Volume 18, Issue 2, Pages 166-167 (February 2016) DOI: 10.1016/j.stem.2016.01.020 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Dynamics of Matrix Mechanical Cues Guide Stem Cell Behavior Stem cells integrate spatiotemporal signals from their microenvironment, e.g., the mechanical properties of the matrix. Within an elastic matrix (most synthetic hydrogels), the energy from mechanical stresses is stored within the static network, just like in a loaded spring. In turn, in viscoelastic matrices (tissues and reversible hydrogels), the stored energy is released by stress-relaxation, modeled as a loaded spring with a damper. Stress-relaxation constitutes a dynamic, mechanical cue guiding signaling within the stem cell, thus modulating spreading, polarization, and differentiation. Cell Stem Cell 2016 18, 166-167DOI: (10.1016/j.stem.2016.01.020) Copyright © 2016 Elsevier Inc. Terms and Conditions