Volume 150, Issue 5, Pages e5 (May 2016)

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R3. 최태웅 / Pf. 장재영 Journal Conference ( ) Association Between Helicobacter pylori Eradication and Gastric Cancer Incidence: A Systematic Review.

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Volume 150, Issue 5, Pages 1113-1124.e5 (May 2016) Association Between Helicobacter pylori Eradication and Gastric Cancer Incidence: A Systematic Review and Meta-analysis Yi-Chia Lee, Tsung-Hsien Chiang, Chu-Kuang Chou, Yu-Kang Tu, Wei-Chih Liao, Ming-Shiang Wu, David Y. Graham Gastroenterology Volume 150, Issue 5, Pages 1113-1124.e5 (May 2016) DOI: 10.1053/j.gastro.2016.01.028 Copyright © 2016 AGA Institute Terms and Conditions

Figure 1 Flow chart of literature search and selection. Gastroenterology 2016 150, 1113-1124.e5DOI: (10.1053/j.gastro.2016.01.028) Copyright © 2016 AGA Institute Terms and Conditions

Figure 2 Summary incidence rate ratio of gastric cancer associated with H pylori eradication by traditional random-effects meta-analysis, stratified by baseline incidence of gastric cancer. Gastroenterology 2016 150, 1113-1124.e5DOI: (10.1053/j.gastro.2016.01.028) Copyright © 2016 AGA Institute Terms and Conditions

Figure 3 Summary incidence rate ratio of gastric cancer associated with H pylori eradication by traditional random-effects meta-analysis, stratified by clinical scenario (asymptomatic infected individuals vs individuals after endoscopic resection of early gastric cancer). Gastroenterology 2016 150, 1113-1124.e5DOI: (10.1053/j.gastro.2016.01.028) Copyright © 2016 AGA Institute Terms and Conditions

Figure 4 Nonlinear relation between incidence rate ratio of gastric cancer associated with H pylori eradication and baseline gastric cancer incidence. IRR, incidence rate ratio. Circles indicate incidence rate ratios in individual studies; size of bubble is proportional to precision (inverse of variance) of incidence rate ratio. Note that the upper bound of 95% CI starts to decrease <1 and becomes statistically significant when the baseline incidence exceeds the threshold value of approximately 150 per 100,000 person-years. Gastroenterology 2016 150, 1113-1124.e5DOI: (10.1053/j.gastro.2016.01.028) Copyright © 2016 AGA Institute Terms and Conditions

Supplementary Figure 1 The funnel plot of all 24 eligible studies does not show asymmetry. Statistical analysis confirmed no evidence of publication bias with Begg’s test (P = .17) and Egger’s test (P = .18). Gastroenterology 2016 150, 1113-1124.e5DOI: (10.1053/j.gastro.2016.01.028) Copyright © 2016 AGA Institute Terms and Conditions