The EMPIR NeuroMET project M. Quaglia, LGC, Queens Road, Teddington, UK

Aim To develop metrological tools and validated minimal/not invasive methods for early diagnosis and drug therapeutic monitoring of Alzheimer's and Parkinson’s diseases

Proposal submitted in October 2015 Project started in July 2016 EURAMET is the Regional Metrology Organisation (RMO) of Europe, which coordinates the cooperation of National Metrology Institutes (NMI) in Europe in fields such as research in metrology, traceability of measurements to the SI units, international recognition of national measurement standards and related Calibration and Measurement Capabilities (CMC). Proposal submitted in October 2015 Project started in July 2016

NeuroMET consortium UK coordinator France Sweden Germany Italy National Measurement Institutes UK coordinator France Sweden Germany Italy Reference methods Immunoassay Statistical analysis MRI/MRS dPCR Partners

Objectives Establishment of patient cohorts (AD including mild cognitive impairment and PD) and matched healthy controls Patient recruitment and stratification by conventional and novel clinical assessment protocols and laboratory analysis in-vivo MRI /MRS protocols at 7T on AD patient cohort (non invasive) Methods for blood biomarker (proteins and miRNA) for early diagnosis on AD and stress monitoring (cortisol) on AD and PD samples (minimally invasive) Reference methods for tau and α-synuclein (comparability) Multimodal statistical analysis of the data with the data from other initiatives to define novel cognitive assessment protocols and validated patient centred outcome measurements

Outputs MRI and MRS protocols Early diagnosis Disease progression monitoring Therapeutics Patient management Cognitive assessment protocols Blood tests (proteins and miRNA) Reference Methods