Elevated Serum Vitamin B12 Levels Associated With CRP as a Predictive Factor of Mortality in Palliative Care Cancer Patients Philippe Geissbühler, MD,

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Presentation transcript:

Elevated Serum Vitamin B12 Levels Associated With CRP as a Predictive Factor of Mortality in Palliative Care Cancer Patients Philippe Geissbühler, MD, Bernadette Mermillod, BSc, Charles-Henri Rapin, MD Journal of Pain and Symptom Management Volume 20, Issue 2, Pages 93-103 (August 2000) DOI: 10.1016/S0885-3924(00)00169-X

Fig 1 Overall survival, first year. Vertical lines correspond to 95% confidence intervals Journal of Pain and Symptom Management 2000 20, 93-103DOI: (10.1016/S0885-3924(00)00169-X)

Fig. 2a Survival according to B12, first year. Vertical lines correspond to 95% confidence interval Journal of Pain and Symptom Management 2000 20, 93-103DOI: (10.1016/S0885-3924(00)00169-X)

Fig. 2b Survival according to B12, five years. Trend test =6.066 (df=1) p = .014 Journal of Pain and Symptom Management 2000 20, 93-103DOI: (10.1016/S0885-3924(00)00169-X)

Fig. 3a Survival according to BCI, first year. Vertical lines correspond to 95% confidence interval Journal of Pain and Symptom Management 2000 20, 93-103DOI: (10.1016/S0885-3924(00)00169-X)

Fig. 3b Survival according to BCI, five years. Trend test = 23.75 (df=1) p < 0.0001 Journal of Pain and Symptom Management 2000 20, 93-103DOI: (10.1016/S0885-3924(00)00169-X)

Fig. 4 Relation between B12, CRP, and Survival. This figure gives a scatterplot of CRP and B12, with observations denoted by circles with area proportional to length of survival. The two lines represent a BCI (CRP multiplied by B12) of 10,000 for the lower one and 40,000 for the upper one. The gray circle represents the only survivor Journal of Pain and Symptom Management 2000 20, 93-103DOI: (10.1016/S0885-3924(00)00169-X)

Fig. 5 Relationship between PINI and CRP, r = 0.96 Journal of Pain and Symptom Management 2000 20, 93-103DOI: (10.1016/S0885-3924(00)00169-X)