Differences in systolic and diastolic BP between patients randomized to atorvastatin or placebo Time point Difference in systolic BP (mm Hg) p Difference in diastolic BP Baseline 0.0 0.95 0.87 6 weeks 0.9 0.02 0.6 0.005 6 months 1.1 0.002 0.001 Closeout 0.1 0.82 0.76 Dahlöf B. American Heart Association Scientific Sessions 2004. Nov 7-10, 2004; New Orleans, LA.

Primary and secondary end points Valsartan 160 mg Valsartan 160 mg/ simvastatin 20 mg Valsartan 160 mg/ simvastatin 80 mg p vs valsartan 160 mg Mean change from baseline in mean 24-hour ASBP (mm Hg) -9.2 -9.3 -9.6 NS Mean change from baseline in mean 24-hour ADBP -5.5 -6.0 LDL (mg/dL) 2.7 -34.8 -47.2 <0.05 CRP (mg/dL) -0.16 -0.2 -0.7 <0.0023 Rajagopalan S. American Heart Association Scientific Sessions 2004. Nov 7-10, 2004; New Orleans, LA.