Cryoglobulinemic Glomerulopathy Complicating Helicobacter pylori–Associated Gastric Mucosa–Associated Lymphoid Tissue Lymphoma  Ammar Almehmi, MD, MPH,

Slides:



Advertisements
Similar presentations
Mark A. Lusco, MD, Agnes B. Fogo, MD, Behzad Najafian, MD, Charles E
Advertisements

Quiz Page June 2007 American Journal of Kidney Diseases
Quiz Page August 2015 American Journal of Kidney Diseases
Mark A. Lusco, MD, Agnes B. Fogo, MD, Behzad Najafian, MD, Charles E
Agnes B. Fogo, MD, Mark A. Lusco, MD, Behzad Najafian, MD, Charles E
Volume 54, Issue 2, Pages (August 1998)
Quiz Page July 2013 American Journal of Kidney Diseases
AJKD Atlas of Renal Pathology: Light Chain Proximal Tubulopathy
Monoclonal Gammopathy–Associated Proliferative Glomerulonephritis
Quiz Page October 2015 American Journal of Kidney Diseases
A 61-Year-Old Man With Membranoproliferative Glomerulonephritis
Agnes B. Fogo, MD, Mark A. Lusco, MD, Behzad Najafian, MD, Charles E
Quiz Page March 2008 American Journal of Kidney Diseases
Infection in Renal Transplantation: A Case of Acute Q Fever
AJKD Atlas of Renal Pathology: Minimal Mesangial and Mesangial Proliferative Lupus Nephritis (ISN/RPS Class I and II)  Agnes B. Fogo, MD, Mark A. Lusco,
Quiz Page December 2007 American Journal of Kidney Diseases
Dense Deposit Disease American Journal of Kidney Diseases
Behzad Najafian, MD, Mark A. Lusco, MD, Laura S. Finn, MD, Charles E
AJKD Atlas of Renal Pathology: Chronic Antibody-Mediated Rejection
Membranoproliferative Glomerulonephritis
AJKD Atlas of Renal Pathology: Fibrillary Glomerulonephritis
Mesangial Proliferative Glomerulonephritis After Autologous Stem Cell Transplantation  Terje Forslund, MD, PhD, Jorma Anttinen, MD, Heikki Hallman, MD,
C3 Glomerulonephritis Associated With Complement Factor B Mutation
Acute Kidney Injury in a Patient Following Kidney Transplantation
AJKD Atlas of Renal Pathology: Cryoglobulinemic Glomerulonephritis
Quiz Page June 2008 American Journal of Kidney Diseases
An Uncommon Cause of Membranous Glomerulonephritis
AJKD Atlas of Renal Pathology: Heavy Chain Deposition Disease
Quiz Page December 2008 American Journal of Kidney Diseases
Postinfectious Glomerulonephritis
Lupus Nephritis: Mesangial and Membranous Forms (WHO II and V)
Deposition of Complement Product C4d in Anti–Glomerular Basement Membrane Glomerulonephritis  Ibrahim Batal, MD, Geetha Chalasani, MD, Christine Wu, MD,
Lupus Nephritis: Proliferative Forms (WHO III, IV)
HIV-associated immune complex glomerulonephritis with “lupus-like” features: A clinicopathologic study of 14 cases1  Mark Haas, Sadhana Kaul, Joseph A.
Nephrotic Syndrome and a Maculopapular Rash
AJKD Atlas of Renal Pathology: Postinfectious Glomerulonephritis
Membranoproliferative Glomerulonephritis, Chronic Lymphocytic Leukemia, and Cryoglobulinemia  Guillaume Favre, MD, PhD, Claire Courtellemont, MD, Patrice.
The Uncertain Significance of Anti–Glomerular Basement Membrane Antibody Among HIV-Infected Persons With Kidney Disease  Lynda Anne Szczech, MD, MSCE,
Toward a working definition of C3 glomerulopathy by immunofluorescence
AJKD Atlas of Renal Pathology: Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits  Mark A. Lusco, MD, Agnes B. Fogo, MD, Behzad.
Volume 88, Issue 4, Pages (October 2015)
A Case of “Pure” Preeclampsia With Nephrotic Syndrome Before 15 Weeks of Gestation in a Patient Whose Renal Biopsy Showed Glomerular Capillary Endotheliosis 
Nephropathy in Illicit Drug Abusers: A Postmortem Analysis
AJKD Atlas of Renal Pathology: Light Chain Deposition Disease
Cryoglobulin-Related Glomerulonephritis
Acute Kidney Failure in the Third Trimester of Pregnancy
An Unusual Case of Urticaria and Nephrotic Syndrome
Volume 65, Issue 1, Pages (January 2004)
Mark A. Lusco, MD, Agnes B. Fogo, MD, Behzad Najafian, MD, Charles E
Acute Kidney Injury and Proteinuria in a Patient With Diabetes and a Submandibular Mass  Prue Hill, MD, PhD, Prue Russell, MD, Christine Sammartino, MD,
Mesangial Proliferative Glomerulonephritis After Autologous Stem Cell Transplantation  Terje Forslund, MD, PhD, Jorma Anttinen, MD, Heikki Hallman, MD,
AJKD Atlas of Renal Pathology: Anti–Glomerular Basement Membrane Antibody– Mediated Glomerulonephritis  Agnes B. Fogo, MD, Mark A. Lusco, MD, Behzad Najafian,
Immunotactoid Glomerulopathy
Marfan Syndrome, MPGN, and Bacterial Endocarditis
Quiz Page November 2006 American Journal of Kidney Diseases
AJKD Atlas of Renal Pathology: IgA Nephropathy
C1q Nephropathy American Journal of Kidney Diseases
Crescentic Glomerulonephritis Associated With Hypocomplementemic Urticarial Vasculitis Syndrome  Leah Balsam, MD, Mohammed Karim, MD, Frederick Miller,
Quiz American Journal of Kidney Diseases
AJKD Atlas of Renal Pathology: Fibronectin Glomerulopathy
Acute Renal Failure due to IgM-λ Glomerular Thrombi and MPGN-Like Lesions in a Patient With Angioimmunoblastic T-Cell Lymphoma  Naoto Miura, MD, Keisuke.
Agnes B. Fogo, MD, Mark A. Lusco, MD, Behzad Najafian, MD, Charles E
Quiz Page September 2015 American Journal of Kidney Diseases
Quiz Page March 2009 American Journal of Kidney Diseases
Quiz Page Answers May 2006 American Journal of Kidney Diseases
Quiz Page January 2010 American Journal of Kidney Diseases
Unmasking a unique glomerular lesion
Quiz page December 2003 American Journal of Kidney Diseases
Cryoglobulinemic Glomerulopathy Complicating Helicobacter pylori–Associated Gastric Mucosa–Associated Lymphoid Tissue Lymphoma  Ammar Almehmi, MD, MPH,
Dysproteinemia and the Kidney: Core Curriculum 2019
Presentation transcript:

Cryoglobulinemic Glomerulopathy Complicating Helicobacter pylori–Associated Gastric Mucosa–Associated Lymphoid Tissue Lymphoma  Ammar Almehmi, MD, MPH, Timothy A. Fields, MD, PhD  American Journal of Kidney Diseases  Volume 54, Issue 4, Pages 770-774 (October 2009) DOI: 10.1053/j.ajkd.2009.04.020 Copyright © 2009 National Kidney Foundation, Inc. Terms and Conditions

Figure 1 Immunofixation electrophoresis of cryoprecipitate. The cryoprecipitate was resuspended in normal saline, processed by using agarose electrophoresis, and stained by using standard immunofixation techniques for immunoglobulin G (IgG), IgA, IgM, Igκ, and Igλ, as indicated. Single bands in the IgM and Igκ lanes reflect the presence of monoclonal IgMκ, and the smear in the IgG lane is indicative of the presence of polyclonal IgG. The first lane contains serum as a standard. American Journal of Kidney Diseases 2009 54, 770-774DOI: (10.1053/j.ajkd.2009.04.020) Copyright © 2009 National Kidney Foundation, Inc. Terms and Conditions

Figure 2 Light microscopic evaluation of the gastric mucosal biopsy specimen. (A) Hematoxylin and eosin–stained section of gastric mucosal biopsy shows dense lymphoid infiltrate; (B) immunohistochemical stain for Helicobacter pylori shows organisms within and on the surface epithelium; (C) immunohistochemical stain shows CD20 expression in the lymphoid cells (brown); and in situ hybridization shows (D) immunoglobulin κ (Igκ) expression within most of the infiltrating lymphocytes (black) and (E) few scattered lymphoid cells expressing Igλ (black). American Journal of Kidney Diseases 2009 54, 770-774DOI: (10.1053/j.ajkd.2009.04.020) Copyright © 2009 National Kidney Foundation, Inc. Terms and Conditions

Figure 3 Light microscopy of the renal biopsy specimen shows membranoproliferative changes. (A) Hematoxylin and eosin, (B) periodic acid–Schiff, and (C) Jones silver-stained images of glomerulus show endocapillary proliferation with lobular accentuation, capillary “thrombi” consisting of cryoglobulins (arrows), and thickened capillary loops with double contours (arrowheads). The bar represents 25 μm. American Journal of Kidney Diseases 2009 54, 770-774DOI: (10.1053/j.ajkd.2009.04.020) Copyright © 2009 National Kidney Foundation, Inc. Terms and Conditions

Figure 4 Renal biopsy specimen using immunofluorescence and electron microscopy. Immunofluorescence microscopy shows intense segmental deposits of (A) immunoglobulin G (IgG) and (B) IgM, corresponding to the large glomerular intracapillary cryoglobulins (arrows) and granular subendothelial deposition of immune complexes within capillary loops (arrowheads). The bar represents 50 μm. (C, D) Electron microscopy shows subendothelial deposit (arrows) and glomerular basement membrane reduplication (arrowheads). (D) The large deposit shows a vaguely organized tubular substructure (original magnification: [C] ×7,100; [D] ×22,000). American Journal of Kidney Diseases 2009 54, 770-774DOI: (10.1053/j.ajkd.2009.04.020) Copyright © 2009 National Kidney Foundation, Inc. Terms and Conditions