Confocal Imaging–Guided Laser Ablation of Basal Cell Carcinomas: An Ex Vivo Study  Heidy Sierra, Miguel Cordova, Chih-Shan Jason Chen, Milind Rajadhyaksha  Journal of Investigative Dermatology  Volume 135, Issue 2, Pages 612-615 (February 2015) DOI: 10.1038/jid.2014.371 Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Reflectance confocal microscopy (RCM) imaging detects the clearance or the presence of residual basal cell carcinoma (BCC) tumor in skin specimens after ablation with 6 passes at fluence of 25 J cm−2. (a) RCM image through stratum of a skin specimen showing BCCs. (b) Enlarged view of region within solid yellow square in a shows details of nodular BCCs. (c) Enlarged view of the region within dashed yellow square in a shows details of BCCs. (d) RCM image of ablated specimen showing exposed dermis. (e) Enlarged view of region within solid yellow square in d shows clearance of tumor after ablation. (f) Enlarged view of ablated region within dashed yellow square in d shows residual nodular BCC. (g) Vertical hematology and eosin histology from dashed orange line in d. (h) Enlarged view of solid black rectangle in g shows normal dermis confirming clearance of tumor after ablation. (i) Enlarged view of dashed black rectangle in g shows residual BCC after ablation. Size bars=500 μm. Journal of Investigative Dermatology 2015 135, 612-615DOI: (10.1038/jid.2014.371) Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions