Figure 1 Specificity of the various epidermal growth factor (EGF)

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Presentation transcript:

Figure 1 Specificity of the various epidermal growth factor (EGF) receptor ligands for the four known ErbB receptors Figure 1 | Specificity of the various epidermal growth factor (EGF) receptor ligands for the four known ErbB receptors. The EGF-related peptide growth factors constitute a family of 11 ligands that bind to receptor tyrosine-protein kinase ErbB receptors. EGF, transforming growth factor α (TGF-α), amphiregulin (AREG), and epigen (EPGN) bind specifically to EGFR (also known as ErbB1). Heparin binding EGF-like growth factor (HB-EGF), epiregulin (EREG), and betacellulin (BTC) show specificity for both ErbB1 and ErbB4. Neuregulins (NRG) bind specifically to ErbB3 or bind to both ErbB3 and ErbB4. Currently, no known ligands have been identified for the ErbB2 receptor. Harskamp, L. R. et al. (2016) The epidermal growth factor receptor pathway in chronic kidney diseases Nat. Rev. Nephrol. doi:10.1038/nrneph.2016.91