Signaling Microdomains

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Signaling Microdomains Friedrich W. Johenning, Barbara E. Ehrlich Neuron Volume 34, Issue 2, Pages 173-175 (April 2002) DOI: 10.1016/S0896-6273(02)00665-7

Figure 1 InsP3 Receptor (InsP3R) Location in the Endoplasmic Reticular Membrane Can Be Modulated by Interactions with Specific Regions of the Plasma Membrane (1) Actin and focal adhesion molecules (fam) can enmesh the InsP3R. (2) Binding between the InsP3R and PIP2 found in lipid rafts can facilitate rapid signaling. (3) Scaffolding proteins such as Vesl/homer can link the InsP3R to specific receptors. (4) InsP3R can bind directly to plasma membrane receptors such as trp. (5) InsP3R can remain unbound in the endoplasmic reticular membrane. Neuron 2002 34, 173-175DOI: (10.1016/S0896-6273(02)00665-7)