Lack of Association Between Proton Pump Inhibitor Use and Cognitive Decline Mette Wod, Jesper Hallas, Kjeld Andersen, Luis Alberto García Rodríguez, Kaare.

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Presentation transcript:

Lack of Association Between Proton Pump Inhibitor Use and Cognitive Decline Mette Wod, Jesper Hallas, Kjeld Andersen, Luis Alberto García Rodríguez, Kaare Christensen, David Gaist Clinical Gastroenterology and Hepatology Volume 16, Issue 5, Pages 681-689 (May 2018) DOI: 10.1016/j.cgh.2018.01.034 Copyright © 2018 AGA Institute Terms and Conditions

Figure 1 Flow-chart of selection of twins for study participation. Clinical Gastroenterology and Hepatology 2018 16, 681-689DOI: (10.1016/j.cgh.2018.01.034) Copyright © 2018 AGA Institute Terms and Conditions

Figure 2 Baseline within-pair analysis. (A) Longitudinal Study of Aging Danish Twins and (B) Middle Age Danish Twins study. Proportion of pairs where the twin exposed to higher cumulative proton pump inhibitor dose at baseline also had lower cognitive score. Proportion estimates above 0.5 (red line) compatible with proton pump inhibitor use associated with larger decline in cognitive function. Proportions calculated for all twin pairs and stratified by the magnitude of intrapair difference in cognitive score; note that the strata are not mutually exclusive. P values above each estimate. Clinical Gastroenterology and Hepatology 2018 16, 681-689DOI: (10.1016/j.cgh.2018.01.034) Copyright © 2018 AGA Institute Terms and Conditions

Figure 3 Longitudinal within-pair analysis. (A) Longitudinal Study of Aging Danish Twins and (B) Middle Age Danish Twins study. Proportion of pairs where the twin exposed to higher cumulative proton pump inhibitor dose during follow-up declined more in cognitive score compared with co-twin. Proportion estimates above 0.5 (red line) compatible with proton pump inhibitor use associated with larger decline in cognitive function. Proportions calculated for all twin pairs and stratified by the magnitude of intrapair difference in cognitive score; note that the strata are not mutually exclusive. P values above each estimate. Clinical Gastroenterology and Hepatology 2018 16, 681-689DOI: (10.1016/j.cgh.2018.01.034) Copyright © 2018 AGA Institute Terms and Conditions