Rebecca E. Graff, Sören Möller, Michael N. Passarelli, John S

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Presentation transcript:

Familial Risk and Heritability of Colorectal Cancer in the Nordic Twin Study of Cancer Rebecca E. Graff, Sören Möller, Michael N. Passarelli, John S. Witte, Axel Skytthe, Kaare Christensen, Qihua Tan, Hans-Olov Adami, Kamila Czene, Jennifer R. Harris, Eero Pukkala, Jaakko Kaprio, Edward L. Giovannucci, Lorelei A. Mucci, Jacob B. Hjelmborg Clinical Gastroenterology and Hepatology Volume 15, Issue 8, Pages 1256-1264 (August 2017) DOI: 10.1016/j.cgh.2016.12.041 Copyright © 2017 AGA Institute Terms and Conditions

Figure 1 Cumulative incidence of colorectal cancer by (A) subsite, (B) sex, (C) country, and (D) zygosity in the Nordic Twin Study of Cancer adjusted for left- and right-censoring and competing risk of death. Clinical Gastroenterology and Hepatology 2017 15, 1256-1264DOI: (10.1016/j.cgh.2016.12.041) Copyright © 2017 AGA Institute Terms and Conditions

Figure 2 Familial risk for colorectal cancer by age adjusted for left- and right-censoring and competing risk of death. Clinical Gastroenterology and Hepatology 2017 15, 1256-1264DOI: (10.1016/j.cgh.2016.12.041) Copyright © 2017 AGA Institute Terms and Conditions

Figure 3 Cumulative heritability in liability to colorectal cancer by 5-year intervals of age at diagnosis, modeling heritability, and common and unique environmental components of liability to disease, adjusted for censoring using inverse probability weighting. Clinical Gastroenterology and Hepatology 2017 15, 1256-1264DOI: (10.1016/j.cgh.2016.12.041) Copyright © 2017 AGA Institute Terms and Conditions

Figure 4 Concordance relative risk of colon and rectal cancer for (A) MZ twins and (B) DZ twins. Clinical Gastroenterology and Hepatology 2017 15, 1256-1264DOI: (10.1016/j.cgh.2016.12.041) Copyright © 2017 AGA Institute Terms and Conditions