Shigella Targets T Cells

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Presentation transcript:

Shigella Targets T Cells John L. Telford, Cosima T. Baldari Cell Host & Microbe Volume 9, Issue 4, Pages 253-254 (April 2011) DOI: 10.1016/j.chom.2011.04.003 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 Impairment of T Cell Chemotaxis by Shigella Schematic representation of the mechanism by which Shigella IpgD impairs T cell migration. Shigella injects the lipid phophatase IpgD into the cytosol of activated CD4+ T cells, causing a reduction in the cortical pool of PIP2 and inactivation of the membrane-cytoskeleton linker ezrin, which results in defective chemotaxis. Cell Host & Microbe 2011 9, 253-254DOI: (10.1016/j.chom.2011.04.003) Copyright © 2011 Elsevier Inc. Terms and Conditions