Geographic distribution in situ of MSI and MSS colorectal cancer–infiltrating lymphocytes. Geographic distribution in situ of MSI and MSS colorectal cancer–infiltrating.

Slides:

Advertisements

Similar presentations

Necropsy of APC Min/+ mice Adenoma in small intestine Spleen 8-10 weeks weeks Normal spleen architecture Expansion of erythroid progenitors.

Advertisements

Figure S1 a b c d DAPI Lgr β-catenin Merge

Ret mouse very large tumors (VLTs) display altered ratios of infiltrating memory to naive T cells: Roles in tumor expansion Mohammad W. Khan, Viktor.

Decreased Expression of the Chromatin Remodeler ATRX Associates with Melanoma Progression Zulekha A. Qadeer, Sara Harcharik, David Valle-Garcia, Chen.

The effect of bisphenol A (BPA) on colon and liver inflammation.

PD-1 and LAG-3 expression in MSI and MSS colorectal cancer specimens.

Proliferating Endothelial Cells and Leukocyte Infiltration as Prognostic Markers in Colorectal Cancer Coen I.M. Baeten, Karolien Castermans, Harry F.P.

Sunitinib plus rMVA–CEA–TRICOM vaccine decreased tumor burden and increased intratumoral infiltration of T lymphocytes in the MC38-CEA colon carcinoma.

IHC staining of FFPE esophageal tissues in tissue microarrays (×20).

Intravenous delivery of reovirus to primary and secondary brain tumors

Fig. 5. Immunohistochemistry of the tumor microenvironment in GBM specimens before and after CART-EGFRvIII infusion. Immunohistochemistry of the tumor.

Functional interaction of Eμ-Tcl1 tumor cells with FDC networks.

Capture of CK+ and CK− complex aneuploid CTCs in breast, ovarian, or colorectal cancer. Capture of CK+ and CK− complex aneuploid CTCs in breast, ovarian,

Deficiency of Cdkn2a leads to aberrant activation of RhoA in vivo.

Tregs and APC subsets in TDLNs of patients with cervical cancer.

Cytotoxic therapy induces CSF1-dependent macrophage recruitment.

PD-1 expression on HCC-infiltrating B cells and its clinical significance. PD-1 expression on HCC-infiltrating B cells and its clinical significance. A–H,

CD169+ macrophages mediate Lm translocation to the splenic T cell zones. CD169+ macrophages mediate Lm translocation to the splenic T cell zones. (A) Confocal.

Elysse C. Filipe et al. BTS 2018;3:38-53

Volume 130, Issue 7, Pages (June 2006)

Inhibition of VEGFA or macrophage-specific ablation of Vegfa from TIE2hi/VEGFAhi TMEM macrophages reduces vascular permeability and tumor cell intravasation.

Phosphorylation of TRIO Y2681 in human colorectal cancer (CRC) is correlated with poorer prognosis. Phosphorylation of TRIO Y2681 in human colorectal cancer.

Effect of antiangiogenic TKIs and rMVA–CEA–TRICOM vaccine on tumor compactness, tight junctions, and intratumoral pressure in the MC38-CEA model. Effect.

Ret mouse very large tumors (VLTs) display altered ratios of infiltrating memory to naive T cells: Roles in tumor expansion Mohammad W. Khan, Viktor.

Correlation of reovirus RNA/protein with proliferating tumor cells

Th1 and CTL-based immune signature and elevated checkpoint expression in MSI colorectal cancer. Th1 and CTL-based immune signature and elevated checkpoint.

ILK knockdown decreases mTOR signaling in PKD kidneys.

Blood Tfr cells show expression of follicular and regulatory markers.

Instigating, noninstigating, and responding human tumor specimens.

DDR1 plays an intrinsic role in primary epithelial cells undergoing branching morphogenesis and is required for correct organization of the basement membrane.

SIRT1 is downregulated in human gastric cancer (GC).

Marked differences in the density, composition and microanatomical distribution of infiltrating immune cells in cutaneous squamous cell carcinoma and the.

A user's perspective on GeoMxTM digital spatial profiling

Autophagy restrains pancreatic inflammation and expression of pTBK1, CCL5, and PD-L1 in vivo. Autophagy restrains pancreatic inflammation and expression.

Combined BRAFi and anti-CTLA4 administration leads to prolonged antitumor immunity in a patient with metastatic melanoma. Combined BRAFi and anti-CTLA4.

Peripheral CAF model. Peripheral CAF model. A, bright field (top) and fluorescence (bottom) micrographs of aggregates that contain RFP-tagged 344SQ cells.

Geographic colocalization of PD-L1+ tumor cells with infiltrating immune cells in MCC. The predominant pattern of tumor cell PD-L1 expression is at the.

Integrated mRNA and microRNA expression and DNA methylation clusters.

PD-L1 expression by melanocytes is observed in geographic association with TILs but does not depend on BRAF V600E. PD-L1 expression by melanocytes is observed.

Antigen-specific CD8+ T cells express higher levels of PD-1 in animals that received the optimized SSX2 vaccine. Antigen-specific CD8+ T cells express.

Overexpression of JMJD2B in clinical bladder cancers.

AXL is not expressed in human prostate tumors.

Antitumor activity of MLN8237 against TNBC patient-derived tumor xenografts (PDTX) in vivo. Antitumor activity of MLN8237 against TNBC patient-derived.

A, TSG-6 staining in TRAMP tissue and TRAMP cell lines.

Distribution of mast cells around the terminal end bud of mice.

Cisplatin plus PTUPB decreases proliferation and angiogenesis but increases apoptosis as determined by immunohistochemical (IHC) analysis. Cisplatin plus.

Overexpression of DDB2 reduces invasive abilities in lungs of aggressive breast tumor cells. Overexpression of DDB2 reduces invasive abilities in lungs.

PVHA increased anti-PD-L1–mediated growth inhibition in 4T1/HAS3 tumors. PVHA increased anti-PD-L1–mediated growth inhibition in 4T1/HAS3 tumors. A, 4T1/HAS3.

Immunohistochemical analysis of dUTPase in human breast adenocarcinoma

Expression of XCR1 in normal ovarian surface epithelium and the IOSE and borderline EOC cell lines. Expression of XCR1 in normal ovarian surface epithelium.

MET amplification is selected in KRAS wild-type colorectal cancer samples from patients who developed resistance to anti-EGFR treatment. MET amplification.

CLIC1 is upregulated in invadopodia of fibrin-embedded tumor and endothelial cells. CLIC1 is upregulated in invadopodia of fibrin-embedded tumor and endothelial.

Ki-67 expression in M31- and H3-treated tumors (A) and respective Ki-67 labeling indices in the two groups of tumors (B). Ki-67 expression in M31- and.

Intratumoral lymphoid aggregates are sites of postvaccination T-cell activation and regulation. Intratumoral lymphoid aggregates are sites of postvaccination.

Example inverse FF-OCT images (left column) and corresponding histology images (right column) of ovarian metastases. Example inverse FF-OCT images (left.

Intratumoral changes in critical lymphocyte populations and numbers after NKTR-214 treatment. Intratumoral changes in critical lymphocyte populations and.

Expression of PCNA, K10, and K5 in skin lesions from Stat3+/−:HPV8 and Stat3+/+:HPV8 mice. Expression of PCNA, K10, and K5 in skin lesions from Stat3+/−:HPV8.

The effect of a DIO regimen ± EPA+DHA supplementation on tumor growth.

Histology (H&E; original magnification, ×100 for B-2P/C-12P/C-64P and ×40 for C-10P; top) of small-sized lung adenocarcinomas and immunohistochemical staining.

Stromal and hematopoietic spleen remodeling in Fas-mutant mice.

Defining the eTME genes.

Phosphorylation of Twist1 in human breast cancer cell lines and tumors

a b c Supplementary Figure 1

Fig. 5 Distributions of cell nuclear area values and internuclear distances in the breast tumor specimens (Figs. 3 and 4), where bin interval = 8 and n.

Coculture with U937 cells enhances DNMT1 expression in gastric cancer cells. Coculture with U937 cells enhances DNMT1 expression in gastric cancer cells.

CD36 expression is coordinately regulated in multiple cellular compartments. CD36 expression is coordinately regulated in multiple cellular compartments.

CD36 expression in tissue adjacent and distal to the tumor.

Coincidence and prognostic significance of PD-1+ and CD103+ cells in HGSC. Serial sections from the 490-case TMA were stained with antibodies to CD103.

IHC staining of FFPE esophageal tissues in tissue microarrays (×20).

Spontaneous PD in DRB1*04:01 mice.

Presentation transcript:

Geographic distribution in situ of MSI and MSS colorectal cancer–infiltrating lymphocytes. Geographic distribution in situ of MSI and MSS colorectal cancer–infiltrating lymphocytes. Formalin-fixed, paraffin-embedded tissue sections were characterized by IHC for CD4+, CD8+, and FOXP3+ cell infiltration. Three distinct histologic areas designated as TIL, tumor stroma, and invasive front (where tumor invaded normal lamina propria) were histologically identified and separately analyzed. Invasive front (A) and TIL/stroma (B) areas of representative MSS (bottom) and MSI (top) specimens are shown (×20 magnification). Dashed lines in A delineate the invasive front with the tumor tissue on the top side and the normal tissue on the bottom side. Red stars and blue arrows in B indicate the tumor stroma and tumor epithelium-infiltrating immune cells, respectively. Scale bars, 100 μm. C, cell density was scored in 14 MSS (blue) and 9 MSI (red) specimens by determining the average number of stained cells in 5 distinct hpf (0.0028 mm2/hpf). The graphs display the mean for each group; *,statistically significant differences between MSS and MSI (P < 0.05, using Mann–Whitney U test). Nicolas J. Llosa et al. Cancer Discovery 2015;5:43-51 ©2015 by American Association for Cancer Research