Volume 147, Issue 2, Pages (August 2014)

Slides:

Advertisements

Similar presentations

Gastric Cancer Risk in Patients With Premalignant Gastric Lesions: A Nationwide Cohort Study in the Netherlands Annemarie C. de Vries, Nicole C.T. van.

Advertisements

Folic Acid Increases Global DNA Methylation and Reduces Inflammation to Prevent Helicobacter-Associated Gastric Cancer in Mice Tamas A. Gonda, Young–In.

Yosuke Toya, Makoto Eizuka, Takayuki Matsumoto Gastroenterology

Immunology and the Lynch Syndrome

Investigation of Outbreak of Infections Caused by Salmonella Saintpaul

Huiqin He, Zhinong Jiang, Leimin Sun Gastroenterology

Corina A. Schmid, Anne Müller Gastroenterology

Byeong–Moo Kim, Michael Y. Choi Gastroenterology

Volume 152, Issue 4, Pages (March 2017)

Pancreatic Mass in a Patient With an Increased Serum Level of IgG4

Christoph Lübbert, Babett Holler Gastroenterology

Volume 151, Issue 2, Pages (August 2016)

Spontaneous Self-Expulsion of a Large Stone From the Abdomen

Outcomes Among Living Liver Donors

Lost in Inflammation: The Functional Conversion of Regulatory T Cells in Acute Hepatitis A Virus Infection Tobias Boettler, Robert Thimme Gastroenterology

Covering the Cover Gastroenterology

How to Critically Read the GI Epidemiology Literature

Gastroenterology 2011–2016: Looking Back and Forward

Making Sense of HDAC2 Mutations in Colon Cancer

Investigation of Outbreak of Infections Caused by Salmonella Saintpaul

Unusual Thickened Gastric Folds in a Patient With Breast Cancer

Volume 134, Issue 5, Pages (May 2008)

Success as a PhD in Gastroenterology

Clinical Challenges and Images in GI

The Changing Liver Transplant Waitlist: An Emerging Liver Purgatory?

Unusual Case of an Upset Stomach

Eva Wertheimer, Marcelo G. Kazanietz Gastroenterology

Volume 155, Issue 4, Pages (October 2018)

Volume 153, Issue 3, Pages e16-e17 (September 2017)

An Unusual Post Gastrectomy Complication

A Historical Perspective on Clinical Advances in Pancreatic Diseases

Volume 150, Issue 4, Pages (April 2016)

Abdominal Pain in a Patient 13 Years After Roux-en-Y Gastric Bypass

Volume 145, Issue 1, Pages (July 2013)

Colon Cancer: An Update and Future Directions

Volume 137, Issue 1, Pages (July 2009)

Immunology and the Lynch Syndrome

Not Your Ordinary Ulcer: A Cautionary Tale of an Uncommon Condition

Covering the Cover Gastroenterology

The 75th Diamond Anniversary of Gastroenterology: 1943–2018

Coffee and Colorectal Cancer: Grounds for Prevention?

Time Trends of Ulcer Mortality in Europe

Volume 133, Issue 2, Pages (August 2007)

Ashwin N. Ananthakrishnan, David Lieberman Gastroenterology

Volume 154, Issue 4, Pages (March 2018)

Volume 148, Issue 3, Pages (March 2015)

Shivan J. Mehta, Kimberly A. Forde Gastroenterology

Gastric Rupture Gastroenterology

Volume 150, Issue 7, Pages (June 2016)

The Rise and Fall (and Rise?) of Endoscopic Anti-Reflux Procedures

Covering the Cover Gastroenterology

The Dawning of a New Editorial Board for Gastroenterology

Richard J. Saad, William D. Chey Gastroenterology

Volume 156, Issue 4, Pages (March 2019)

Advances in Minimally Invasive Surgery

Changing of the Guards: 2011–2016 Gastroenterology Team

Volume 156, Issue 4, Pages (March 2019)

Volume 155, Issue 6, Pages (December 2018)

Volume 139, Issue 6, Pages e1 (December 2010)

Esophageal Tumor After Radical Surgery for Gastric Cancer

Cancer Costs Projected to Reach at Least $158 Billion in 2020

Volume 138, Issue 6, Pages (May 2010)

End-Stage Liver Disease in 2008: Finally a Glass Half Full

Reinvesting in US Biomedical Research—The Time is Now

Electronic Clinical Challenges and Images in GI

The Future of Endoscopic Retrograde Cholangiopancreatography

Controversies in Liver Transplantation for Hepatitis C

Volume 138, Issue 2, Pages (February 2010)

Unrelenting Abdominal Pain after Recent Initiation of a Direct Oral Anticoagulant: A Cause for Concern Nicholas R. Crews, Nabil Fayad Gastroenterology

Abnormal Gastrointestinal Imaging in a Patient With Dyspepsia

Presentation transcript:

Volume 147, Issue 2, Pages 267-269 (August 2014) Mutational Signatures in Helicobacter pylori–induced Gastric Cancer: Lessons From New Sequencing Technologies Sarah Derks Gastroenterology Volume 147, Issue 2, Pages 267-269 (August 2014) DOI: 10.1053/j.gastro.2014.06.019 Copyright © 2014 AGA Institute Terms and Conditions

Figure 1 Two pathways of C>T mutation in gastric cancer. (Above arrow) Activation-induced deamination (AID) removes the amino group of cytosine turning it into uracil. (Below arrow) Cytosine methylation induced deamination. The binding of a methyl group to the 5-carbon position of the cytosine ring results in 5-methylcytosine. A 5-methylcytosine spontaneously deaminates into an uracil. The uracil is replaced by a thymine after DNA replication. Gastroenterology 2014 147, 267-269DOI: (10.1053/j.gastro.2014.06.019) Copyright © 2014 AGA Institute Terms and Conditions