different types of liver cells

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Daniela Sia, Augusto Villanueva, Scott L. Friedman, Josep M. Llovet

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by Edward E. Morrisey Circulation Research Volume 109(6):

Figure 2 Inflammatory pathways affecting hepatic insulin resistance

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Figure 2 Crosstalk between TGF-β/Smad and other pathways in tissue fibrosis Figure 2 | Crosstalk between TGF-β/Smad and other pathways in tissue fibrosis.

Figure 3 Extracellular stimuli to HSC activation

Figure 4 Activation of clopidogrel via cytochrome P450

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Figure 5 Lipid droplet consumption

Figure 3 Life cycle of hepatitis E virus

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Figure 1 Towards precision PRRT for neuroendocrine tumours

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Figure 3 Histological subtypes of intrahepatic CCA

Figure 3 The 'leaky gut' hypothesis

Figure 2 Effect of PPIs on gastric physiology

Figure 4 Giant lipid droplet formation

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Figure 6 Combination therapy for HCC

Figure 1 Definition and concept of ACLF

Daniela Sia, Augusto Villanueva, Scott L. Friedman, Josep M. Llovet

Figure 1 Functions, features and phenotypes of HSCs in normal and diseased livers Figure 1 | Functions, features and phenotypes of HSCs in normal and diseased.

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Figure 2 Switching of biologic agents and biosimilars

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Figure 1 Overview of the immunopathogenesis of ulcerative colitis

Figure 2 Roles of mTOR complexes in the kidney

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Figure 1 mTOR complex biology

to the liver and promote patient-derived xenograft tumour growth

Nat. Rev. Nephrol. doi: /nrneph

Figure 5 Hepatic regeneration in ACLF

Figure 2 13C-octanoic acid gastric emptying breath test

in the UK (1961–2012), France (1961–2014) and Italy (1961–2010)

Volume 137, Issue 1, Pages (July 2009)

Figure 1 Simplified representation of the physiological

BMP Receptor 1a and Juvenile Polyposis Syndrome

Figure 3 Lipid droplet formation and expansion

Figure 1 Key mechanistic pathways involved in the gut–liver axis in NAFLD progression Figure 1 | Key mechanistic pathways involved in the gut–liver axis.

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Figure 6 Possible therapeutic targets to decrease hepatic steatosis

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Figure 2 Schematic of normal and abnormal liver regeneration

Figure 1 Animal models of liver regeneration

Figure 3 Strategies to improve liver regeneration

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Bile Acids Activate YAP to Promote Liver Carcinogenesis

Figure 5 Systems biological model of IBS

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YAPping About Glutaminolysis in Hepatic Fibrosis

Figure 1 Mucosal immune networks

Figure 4 Role of exosomes in the pathogenesis of alcoholic hepatitis

Figure 1 Main triggers of senescence

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Figure 3 Bile acid-induced hepatic inflammation and carcinogenesis

Figure 2 Lifelong influences on the gut microbiome from

Bile Acids Activate YAP to Promote Liver Carcinogenesis

Hippo Signaling Maintains the Phenotype of Pancreatic Acinar Cells

Figure 4 Bile-acid-induced TGR5 signalling pathways in macrophages

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Mst Out and HCC In Cancer Cell

Foxa1 and Foxa2 regulate bile duct development in mice

Figure 1 The spread of colorectal cancer metastases

Volume 13, Issue 3, Pages (March 2008)

Fig. 4. miR promotes cardiomyocyte proliferation through regulation of Hippo pathway kinases. miR promotes cardiomyocyte proliferation through.

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different types of liver cells Figure 6 Hippo pathway has roles in organ size control and carcinogenesis in different types of liver cells Figure 6 | Hippo pathway has roles in organ size control and carcinogenesis in different types of liver cells. Disruption of Hippo signalling by deleting core kinase components (MST1, MST2, SAV1, MOB1A, MOB1B, LATS1, LATS2 and Merlin) leads to uncontrolled proliferation of hepatocytes and bile duct epithelial cells (cholangiocytes). Transgenic mice with deficiency in Hippo pathway show spontaneous liver tumours derived from hepatocytes and/or cholangiocytes, as well as hepatomegaly caused by expansion of hepatocytes. Notably, Sav1-knockout mice exhibit expansion of hepatic progenitor cells, which is not observed in mice with deficiency of other Hippo pathway components. On the other hand, induced ectopic expression of YAP1 converts hepatocytes into progenitor or ductal-like cells. These observations indicate a unique role of SAV1 in regulating YAP1 activities in hepatic progenitor roles. LATS, large tumour suppressor; MOB1, Mob1 homologue protein; MST, mammalian ste20-like kinase; SAV1, salvador family WW domain-containing protein 1; YAP1, Yes-associated protein 1. Hong, A. W. et al. (2016) The Hippo pathway in intestinal regeneration and disease Nat. Rev. Gastroenterol. Hepatol. doi:10.1038/nrgastro.2016.59